Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production
| Autor: | Yan Li, Xing-De Wu, Ya-Dong Guo, Juan He, Liang Deng, Li-Yan Peng, Xing-Yao Li, Jing Zhang, Zhi-Bin Qin, Qin-Shi Zhao, Lin-Fen Ding |
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| Rok vydání: | 2014 |
| Předmět: |
Lipopolysaccharides
Magnetic Resonance Spectroscopy Pharmaceutical Science Tussilago Tussilagone Flowers Biology Nitric Oxide Inhibitory postsynaptic potential Analytical Chemistry Nitric oxide Inhibitory Concentration 50 Mice chemistry.chemical_compound Cell Line Tumor Drug Discovery Botany Ic50 values Animals Inhibitory concentration 50 Pharmacology Plants Medicinal Molecular Structure Organic Chemistry Asteraceae biology.organism_classification Nitric oxide metabolism Antitussive Agents Complementary and alternative medicine chemistry Molecular Medicine Sesquiterpenes Drugs Chinese Herbal |
| Zdroj: | Planta Medica. 80:703-709 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0034-1368567 |
| Popis: | Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 mu M. |
| Databáze: | OpenAIRE |
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