Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection
| Autor: | Smita S. Iyer, Steven E. Bosinger, Hadia M. Abdelaal, Daniel Rios, Sakeenah L. Hicks, Rafi Ahmed, Ifor R. Williams, Gregory K. Tharp, Geetha H. Mylvaganam, Maud Mavigner, Ann Chahroudi, Vijayakumar Velu, Rama Rao Amara, Pamela J. Skinner |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Receptors CXCR5 0301 basic medicine Simian Acquired Immunodeficiency Syndrome CD8-Positive T-Lymphocytes Biology Corrections CCL5 03 medical and health sciences Interleukin 21 0302 clinical medicine Animals Cytotoxic T cell IL-2 receptor Antigen-presenting cell Interleukin 3 Multidisciplinary Germinal Center Natural killer T cell Macaca mulatta Virology 030104 developmental biology Chronic Disease Immunology Interleukin 12 Simian Immunodeficiency Virus 030215 immunology |
| Zdroj: | Proceedings of the National Academy of Sciences. 114:1976-1981 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1621418114 |
| Popis: | A significant challenge to HIV eradication is the elimination of viral reservoirs in germinal center (GC) T follicular helper (Tfh) cells. However, GCs are considered to be immune privileged for antiviral CD8 T cells. Here, we show a population of simian immunodeficiency virus (SIV)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required for homing to GCs) and expand in lymph nodes (LNs) following pathogenic SIV infection in a cohort of vaccinated macaques. This expansion was greater in animals that exhibited superior control of SIV. The CXCR5+ SIV-specific CD8 T cells demonstrated enhanced polyfunctionality, restricted expansion of antigen-pulsed Tfh cells in vitro , and possessed a unique gene expression pattern related to Tfh and Th2 cells. The increase in CXCR5+ CD8 T cells was associated with the presence of higher frequencies of SIV-specific CD8 T cells in the GC. Following TCR-driven stimulation in vitro, CXCR5+ but not CXCR5– CD8 T cells generated both CXCR5+ as well as CXCR5– cells. However, the addition of TGF-β to CXCR5– CD8 T cells induced a population of CXCR5+ CD8 T cells, suggesting that this cytokine may be important in modulating these CXCR5+ CD8 T cells in vivo. Thus, CXCR5+ CD8 T cells represent a unique subset of antiviral CD8 T cells that expand in LNs during chronic SIV infection and may play a significant role in the control of pathogenic SIV infection. |
| Databáze: | OpenAIRE |
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