A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation
| Autor: | Courtney A. Schreiber, Mitchell D. Creinin, Amitasrigowri S. Murthy, Bryna Harwood |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors medicine.medical_treatment Gestational sac Pilot Projects Abortion Incomplete Abortion Pregnancy Humans Medicine Misoprostol Abortifacient Gynecology Abortifacient Agents Nonsteroidal business.industry Obstetrics Abortifacient Agents Steroidal Obstetrics and Gynecology Abortion Induced Vaginal ultrasonography Mifepristone Medical abortion Administration Intravaginal Drug Combinations Pregnancy Trimester First medicine.anatomical_structure Reproductive Medicine Female business medicine.drug |
| Zdroj: | Contraception. 71:333-336 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/j.contraception.2004.10.006 |
| Popis: | Hypothesis Simultaneous administration of mifepristone and misoprostol for medical abortion in women up to 49 days gestation will result in complete abortion in 90% of women within 24 h of treatment. Materials and Methods Forty women with pregnancies up to 49 days gestation inserted 800 μg vaginal misoprostol in our office immediately after taking mifepristone 200 mg orally. Follow-up visits, which included vaginal ultrasonography, occurred 24±1 h and 2 weeks after treatment. If a gestational sac was still present at the first follow-up visit, the misoprostol dose was repeated. Suction abortion was performed for a viable gestation at the second follow-up visit, presence of a nonviable gestation within 5 weeks of treatment and when clinically indicated. Results Expulsion occurred in 36/40 (90%, 95% CI 80–99) and 39/40 (98%, 95% CI 93–100) women by the first and second follow-up visits, respectively. One woman who had initially expelled the gestational sac after a single dose of misoprostol later required a suction curettage for an incomplete abortion. Conclusion Simultaneous administration of mifepristone and vaginal misoprostol is a promising regimen for medical abortion up to 49 days gestation. |
| Databáze: | OpenAIRE |
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