Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization
| Autor: | Haimin Li, Donna William, Ding Xue, Shohei Mitani, Riley Robert Skeen-Gaar, Qinghua Zhou, Eui Seung Lee, Akihisa Nakagawa, Byung-Ho Kang, Brian L. Harry, Hanzeng Li, Yuji Suehiro, Hanna S. Yuan, Jason L.J. Lin |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Autophagosome Proteasome Endopeptidase Complex Mitochondrial DNA Embryo Nonmammalian Mitochondrial Degradation Mitochondrion DNA Mitochondrial Article Mitochondrial Proteins 03 medical and health sciences Autophagy Animals Inner membrane Caenorhabditis elegans Caenorhabditis elegans Proteins Genetics Endodeoxyribonucleases Multidisciplinary biology biology.organism_classification Spermatozoa Mitochondria Cell biology 030104 developmental biology Fertilization Mitochondrial Membranes Intermembrane space |
| Zdroj: | Science. 353:394-399 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aaf4777 |
| Popis: | Eliminating paternal mitochondria During fertilization, the oocyte and sperm each bring their mitochondria to the union. Shortly afterward, the paternal mitochondria are degraded, and only the maternal mitochondria are conveyed to the progeny. Zhou et al. observed that the integrity of the inner membrane of paternal mitochondria is compromised, which apparently marks them for degradation (see the Perspective by van der Bliek). Autophagy commences by mitochondrial endonuclease G relocating from the intermembrane space into the matrix and subsequently degrading the paternal mitochondrial DNA. Any delay in this process increases embryonic lethality. Science , this issue p. 394 ; see also p. 351 |
| Databáze: | OpenAIRE |
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