Sperm interaction with the uterine innate immune system: toll-like receptor 2 (TLR2) is a main sensor in cattle
| Autor: | Masayuki Shimada, Yejin Kim, Susan S. Suarez, Akio Miyamoto, Ihshan Akthar, Mohamed Ali Marey |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Uterus Reproductive technology Biology Endometrium Endocrinology Immune system Genetics medicine Animals Molecular Biology reproductive and urinary physiology Fertilisation Toll-like receptor Innate immune system urogenital system Sperm Spermatozoa Immunity Innate Toll-Like Receptor 2 Cell biology TLR2 medicine.anatomical_structure Reproductive Medicine Immune System Animal Science and Zoology Cattle Female Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 34(2) |
| ISSN: | 1031-3613 |
| Popis: | During the passage through the female reproductive tract, sperm interact with various compartments and their immune systems. The immune system that protects the female against pathogens also could destroy sperm or prevent them from reaching the site of fertilisation. In particular, the uterine innate immune response is crucial from the perspectives of both the sperm and the uterus. Following insemination, sperm immediately start to trigger inflammation in the uterus by entering uterine glands and activating an innate immune response. In cattle, the activation occurs mainly via TLR2 signalling, if not the only one, between sperm and the uterine epithelium lining the glands. This acute immune response is manifested as the upregulation of mRNA expression of IL8, TNFA, IL1B, and PGES. As a consequence, many sperm are trapped by polymorphonuclear neutrophils, the first and major component of innate immunity. The sperm-induced uterine innate immune responses apparently serve to clear the uterus of excess sperm and, importantly, prepare the endometrium for implantation. Pathophysiological conditions in the uterus seriously disrupt this phenomenon, and thus could directly decrease fertility. |
| Databáze: | OpenAIRE |
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