A Stretchable Microneedle Electrode Array for Stimulating and Measuring Intramuscular Electromyographic Activity
| Autor: | Swaminathan Rajaraman, Gareth S. Guvanasen, Chancellor S. Shafor, T. Richard Nichols, Ricardo Aguilar, Liang Guo, Stephen P. DeWeerth, Ashton L. Cheek |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Muscle Fibers Skeletal Biomedical Engineering Action Potentials 02 engineering and technology Electromyography 01 natural sciences Sensitivity and Specificity Synaptic Transmission chemistry.chemical_compound Elastic Modulus Tensile Strength Internal Medicine Signal fidelity medicine Electrode array Electric Impedance Animals Humans Cells Cultured Motor Neurons Polydimethylsiloxane medicine.diagnostic_test General Neuroscience 010401 analytical chemistry Rehabilitation Reproducibility of Results Equipment Design 021001 nanoscience & nanotechnology Microarray Analysis Electric Stimulation 0104 chemical sciences Electrodes Implanted Rats Motor unit Equipment Failure Analysis Microelectrode Electrophysiology chemistry Needles Electrode 0210 nano-technology Microelectrodes Biomedical engineering Muscle Contraction |
| Zdroj: | IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 25(9) |
| ISSN: | 1558-0210 |
| Popis: | We have developed a stretchablemicroneedle electrode array (sMEA) to stimulate andmeasure the electrical activity of muscle across multiple sites. The technology provides the signal fidelity and spatial resolution of intramuscular electrodesacross a large area of tissue. Our sMEA is composed of a polydimethylsiloxane (PDMS) substrate, conductive-PDMS traces, and stainless-steel penetrating electrodes. The traces and microneedles maintain a resistance of less than 10 $\text {k}\Omega $ when stretched up to a ~63% tensile strain, which allows for the full range of physiological motion of felinemuscle. The device and its constituent materials are cytocompatible for at least 28 days in vivo . When implanted in vivo , the device measures electromyographic (EMG) activity with clear compound motor unit action potentials. The sMEA also maintains a stable connection with moving muscle while electrically stimulating the tissue. This technology has direct application to wearable sensors, neuroprostheses, and electrophysiological studies of animals and humans. |
| Databáze: | OpenAIRE |
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