Intake of up to 3 Eggs per Day Is Associated with Changes in HDL Function and Increased Plasma Antioxidants in Healthy, Young Adults
| Autor: | Christopher N. Blesso, Gregory H Norris, Courtney L. Millar, Diana M DiMarco, Maria Luz Fernandez |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Lutein Adolescent Apolipoprotein B Eggs Medicine (miscellaneous) 030204 cardiovascular system & hematology Antioxidants Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Cholesterylester transfer protein medicine Humans Carotenoid chemistry.chemical_classification Cross-Over Studies Nutrition and Dietetics biology Aryldialkylphosphatase Chemistry Cholesterol HDL Diet Zeaxanthin Apolipoproteins 030104 developmental biology Endocrinology Acyltransferase biology.protein Female lipids (amino acids peptides and proteins) Phosphatidylcholine—sterol O-acyltransferase Lipoprotein |
| Zdroj: | The Journal of Nutrition. 147:323-329 |
| ISSN: | 1541-6100 0022-3166 |
| DOI: | 10.3945/jn.116.241877 |
| Popis: | Background: HDL function may be more important than HDL concentration in determining risk for cardiovascular disease. In addition, HDL is a carrier of carotenoids and antioxidant enzymes, which protect HDL and LDL particles against oxidation.Objective: The goal of this study was to determine the impact of consuming 0-3 eggs/d on LDL and HDL particle size, HDL function, and plasma antioxidants in a young, healthy population.Methods: Thirty-eight healthy men and women [age 18-30 y, body mass index (in kg/m2) 18.5-29.9] participated in this 14-wk crossover intervention. Subjects underwent a 2-wk washout (0 eggs/d) followed by sequentially increasing intake of 1, 2, and 3 eggs/d for 4 wk each. After each period, fasting blood was collected for analysis of lipoprotein subfractions, plasma apolipoprotein (apo) concentration, lutein and zeaxanthin concentration, and activities of lecithin-cholesterol acyltransferase, cholesteryl ester transfer protein, and paraoxonase-1.Results: Compared with intake of 0 eggs/d, consuming 1-3 eggs/d resulted in increased large-LDL (21-37%) and large-HDL (6-13%) particle concentrations, plasma apoAI (9-15%), and lecithin-cholesterol acyltransferase activity (5-15%) (P < 0.05 for all biomarkers). Intake of 2-3 eggs/d also promoted an 11% increase in apoAII (P < 0.05) and a 20-31% increase in plasma lutein and zeaxanthin (P < 0.05), whereas intake of 3 eggs/d resulted in a 9-16% increase in serum paraoxonase-1 activity compared with intake of 1-2 eggs/d (P < 0.05). Egg intake did not affect cholesteryl ester transfer protein activity.Conclusions: Intake of 1 egg/d was sufficient to increase HDL function and large-LDL particle concentration; however, intake of 2-3 eggs/d supported greater improvements in HDL function as well as increased plasma carotenoids. Overall, intake of ≤3 eggs/d favored a less atherogenic LDL particle profile, improved HDL function, and increased plasma antioxidants in young, healthy adults. This trial was registered at clinicaltrials.gov as NCT02531958. |
| Databáze: | OpenAIRE |
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