MiR-126-5p regulates osteolysis formation and stromal cell proliferation in giant cell tumor through inhibition of PTHrP

Autor:	Tielong Liu, Huabin Yin, Ting Wang, Wei Xu, Wangjun Yan, Jia Chen, Zhenxi Li, Haiyan Chen, Wang Zhou, Jianru Xiao, Dianwen Song, Xinghai Yang, Zhipeng Wu
Rok vydání:	2014
Předmět:	musculoskeletal diseases medicine.medical_specialty Histology Stromal cell Osteolysis Cell cycle checkpoint Physiology Endocrinology Diabetes and Metabolism Molecular Sequence Data Down-Regulation Giant Cells Osteoclast Cell Line Tumor Internal medicine medicine Animals Humans Bone Resorption Cell Proliferation Regulation of gene expression Base Sequence Chemistry Cell growth Gene Expression Profiling Giant Cell Tumors Parathyroid Hormone-Related Protein Cell Cycle Checkpoints Endonucleases medicine.disease Gene Expression Regulation Neoplastic Mice Inbred C57BL MicroRNAs HEK293 Cells medicine.anatomical_structure Endocrinology Cell culture Giant cell Cancer research Stromal Cells Genetic Engineering hormones hormone substitutes and hormone antagonists
Zdroj:	Bone. 66:267-276
ISSN:	8756-3282
Popis:	Parathyroid hormone-related protein (PTHrP) has been identified to play a crucial role in osteolysis formation and stromal cell (GCTSC) proliferation in giant cell tumor (GCT). MiR-126-5p is an intronic miRNA identified as tumor suppressor in many tumors, but its role in GCT is poorly understood. We found that miR-126-5p was decreased in GCT and could directly regulate PTHrP expression. Furthermore, miR-126-5p could control osteoclast (OC) differentiation, GCTSC proliferation and osteolysis formation in GCT through negative regulation of PTHrP. Thus, these results suggest that miR-126-5p could directly target PTHrP and have a tumor suppressor function in GCT.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4984783a0f6549682496b47a81beffe6 https://doi.org/10.1016/j.bone.2014.06.021 Zobrazit plný text záznamu Full Text from ScienceDirect