Management of Newly Diagnosed Symptomatic Multiple Myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines
| Autor: | S. Vincent Rajkumar, Angela Dispenzieri, Vivek Roy, Joseph R. Mikhael, Philip R. Greipp, P. Leif Bergsagel, Rafael Fonseca, Robert A. Kyle, David Dingli, Craig B. Reeder, Steven R. Zeldenrust, Suzanne R. Hayman, A. Keith Stewart, Francis K. Buadi, Morie A. Gertz, John A. Lust, Shaji Kumar, Martha Q. Lacy, Stephen J. Russell, Thomas E. Witzig, Kristen Detweiler Short, Robert J. Dalton |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Review Disease Risk Assessment law.invention Randomized controlled trial law Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Humans Combined Modality Therapy Progression-free survival Intensive care medicine Multiple myeloma business.industry Retrospective cohort study General Medicine Plasma cell neoplasm medicine.disease Surgery Practice Guidelines as Topic Multiple Myeloma business Monoclonal gammopathy of undetermined significance Stem Cell Transplantation |
| Zdroj: | Mayo Clinic Proceedings. 84:1095-1110 |
| ISSN: | 0025-6196 |
| DOI: | 10.4065/mcp.2009.0603 |
| Popis: | Multiple myeloma is a malignant plasma cell neoplasm that affects more than 20,000 people each year and is the second most common hematologic malignancy. It is part of a spectrum of monoclonal plasma cell disorders, many of which do not require active therapy. During the past decade, considerable progress has been made in our understanding of the disease process and factors that influence outcome, along with development of new drugs that are highly effective in controlling the disease and prolonging survival without compromising quality of life. Identification of well-defined and reproducible prognostic factors and introduction of new therapies with unique modes of action and impact on disease outcome have for the first time opened up the opportunity to develop risk-adapted strategies for managing this disease. Although these risk-adapted strategies have not been prospectively validated, enough evidence can be gathered from existing randomized trials, subgroup analyses, and retrospective studies to develop a working framework. This set of recommendations represents such an effort—the development of a set of consensus guidelines by a group of experts to manage patients with newly diagnosed disease based on an interpretation of the best available evidence. |
| Databáze: | OpenAIRE |
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