Impact of caffeine on myocardial perfusion reserve assessed by semiquantitative adenosine stress perfusion cardiovascular magnetic resonance

Autor: Philipp Kaesemann, Raffi Bekeredjian, Simon Greulich, Maria Chatzitofi, Gloria Tauscher, Andreas Seitz, Udo Sechtem, Heiko Mahrholdt, Stephanie Löbig
Rok vydání: 2019
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Adenosine
Vasodilator Agents
Myocardial Ischemia
Vasodilation
030218 nuclear medicine & medical imaging
chemistry.chemical_compound
0302 clinical medicine
Ischemia
MPRI
Prospective Studies
Cardiac imaging
Radiological and Ultrasound Technology
medicine.diagnostic_test
Myocardial Perfusion Imaging
Middle Aged
Myocardial perfusion reserve
Cardiology
Female
Cardiology and Cardiovascular Medicine
Caffeine
Perfusion
medicine.drug
medicine.medical_specialty
Magnetic Resonance Imaging
Cine
Hyperemia
03 medical and health sciences
Predictive Value of Tests
Coronary Circulation
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Adenosine stress CMR
Aged
Angiology
business.industry
Research
Reproducibility of Results
Magnetic resonance imaging
Splenic switch-off
medicine.disease
Purinergic P1 Receptor Antagonists
chemistry
lcsh:RC666-701
business
Zdroj: Journal of Cardiovascular Magnetic Resonance, Vol 21, Iss 1, Pp 1-10 (2019)
Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Popis: Background Adenosine is used in stress perfusion cardiac imaging to reveal myocardial ischemia by its vasodilator effects. Caffeine is a competitive antagonist of adenosine. However, previous studies reported inconsistent results about the influence of caffeine on adenosine's vasodilator effect. This study assessed the impact of caffeine on the myocardial perfusion reserve index (MPRI) using adenosine stress cardiovascular magnetic resonance imaging (CMR). Moreover, we sought to evaluate if the splenic switch-off sign might be indicative of prior caffeine consumption. Methods Semiquantitative perfusion analysis was performed in 25 patients who underwent: 1) caffeine-naïve adenosine stress CMR demonstrating myocardial ischemia and, 2) repeat adenosine stress CMR after intake of caffeine. MPRI (global; remote and ischemic segments), and splenic perfusion ratio (SPR) were assessed and compared between both exams. Results Global MPRI after caffeine was lower vs. caffeine-naïve conditions (1.09 ± 0.19 vs. 1.24 ± 0.19; p
Databáze: OpenAIRE
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