Re-establishing tolerance to DNA in humanized and murine models of SLE
| Autor: | Nikolina Mihaylova, Elisaveta Voynova, Kalina Nikolova, Nikola Kerekov, Vera Gesheva, Andrey Tchorbanov, Maria Nikolova, József Prechl |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Immunology B-cell receptor Naive B cell Monoclonal antibody Protein Engineering Immune tolerance chemistry.chemical_compound Mice immune system diseases Biomimetics Antibodies Bispecific medicine Immune Tolerance Immunology and Allergy Animals Humans Lupus Erythematosus Systemic skin and connective tissue diseases Receptor Feedback Physiological B-Lymphocytes biology Immunotherapy DNA Molecular biology Disease Models Animal chemistry Antibodies Antinuclear biology.protein Antibody |
| Zdroj: | Autoimmunity reviews. 9(7) |
| ISSN: | 1873-0183 |
| Popis: | DNA-specific B cells in SLE represent a logical target for therapeutic intervention. We hypothesize that it is possible to re-establish tolerance to native DNA in SCID mice with cells transferred from SLE patients or from lupus-prone MRL/lpr mice by administering chimeric molecules, containing a monoclonal antibody against inhibitory B cell receptors coupled to a peptide that antigenically mimics DNA. These protein-engineered molecules are able to co-crosslink selectively the antigen receptors of B cells possessing anti-native DNA specificity with the inhibitory surface receptors, thus delivering a strong suppressive signal. |
| Databáze: | OpenAIRE |
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