Acute intermittent porphyria and caesarean delivery
| Autor: | Stephen H. Rolbin, Gareth Kantor |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Lidocaine medicine.medical_treatment Fentanyl chemistry.chemical_compound Porphyrias Pregnancy Recurrence Porphobilinogen medicine Anesthesia Obstetrical Humans General anaesthesia Caesarean section skin and connective tissue diseases Propofol Acute intermittent porphyria business.industry Cesarean Section nutritional and metabolic diseases General Medicine medicine.disease Surgery Pregnancy Complications Anesthesiology and Pain Medicine Porphyria chemistry Anesthesia Acute Disease Anesthesia Intravenous Female business medicine.drug |
| Zdroj: | Canadian journal of anaesthesia = Journal canadien d'anesthesie. 39(3) |
| ISSN: | 0832-610X |
| Popis: | A 29-yr-old patient was diagnosed with acute intermittent porphyria (AIP) during pregnancy. She had a Caesarean section under lidocaine/fentanyl epidural blockade. Because of inadequate analgesia, general anaesthesia was induced with propofol. Postoperatively urinary porphobilinogen excretion (625 μmol · day−1) exceeded the upper limit of normal but no symptoms of porphyria developed. In anecdotal clinical reports and in a previously described rat model of porphyria, propofol was found to be safe. This is the first reported use of propofol in a pregnant porphyric patient. Anaesthetic drug safety in porphyria is reviewed and the choice of induction agent discussed. Data on which to base these decisions is limited but we conclude that propofol may be suitable for use in patients with porphyria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink