Hypertension Causes Premature Aging of Endothelial Function in Humans
| Autor: | Paola Mattei, Agostino Virdis, Isabella Sudano, Antonio Salvetti, Stefano Taddei, Ciro Basile Fasolo, Lorenzo Ghiadoni |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Nitroprusside Senescence Premature aging Aging medicine.medical_specialty Endothelium Vasodilator Agents Vasodilation Arginine Nitric oxide chemistry.chemical_compound Internal medicine Internal Medicine medicine Humans Drug Interactions Endothelial dysfunction Aged business.industry Middle Aged medicine.disease Acetylcholine Endocrinology medicine.anatomical_structure chemistry Blood Circulation Hypertension Female Sodium nitroprusside business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.29.3.736 |
| Popis: | We designed the present study to evaluate whether in normotensive subjects and hypertensive patients aging causes endothelial dysfunction by a defect in the L-arginine–nitric oxide pathway or production of cyclooxygenase-dependent vasoconstrictors. In 43 normotensive subjects and 47 essential hypertensive patients, we evaluated forearm blood flow (strain-gauge plethysmography) modifications evoked by intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 μg/100 mL per minute), an endothelium-dependent vasodilator, in the presence of saline, l -arginine (1 μmol/100 mL per minute), or indomethacin (50 μg/100 mL per minute), a cyclooxygenase inhibitor, and by sodium nitroprusside (1, 2, and 4 μg/100 mL per minute), an endothelium-independent vasodilator. Vasodilation to acetylcholine was lower ( P l -arginine potentiated the response to acetylcholine in parallel with increasing age, whereas indomethacin increased the vasodilation to acetylcholine only in the oldest group (>60 years). In younger hypertensive patients (l -arginine but not indomethacin potentiated the response to acetylcholine. In adult patients (31 to 45 years), l -arginine still potentiated the vasodilation to acetylcholine, and indomethacin began to show some effect. In the oldest patients (46 to 60 and >60 years), l -arginine was no longer effective, and indomethacin exerted a potentiating action that was positively related to advancing age. In normotensive and hypertensive humans, similar mechanisms, including dysfunction of the nitric oxide pathway and production of cyclooxygenase-dependent vasoconstrictors, cause age-related impairment of endothelium-dependent vasodilation, and only their earlier appearance characterizes hypertensive disease. Thus, the endothelial dysfunction that occurs in hypertension seems to represent an accelerated form of dysfunction that occurs in aging. |
| Databáze: | OpenAIRE |
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