Improvement in adherence to antibiotic duration of therapy recommendations for uncomplicated cystitis: a quasi-experimental study
| Autor: | Steven E Spencer, James K. Aden, Stephanie E Giancola, John M Higginbotham, Alice E Barsoumian, Deena E Sutter |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Antibiotics Antimicrobial Stewardship Young Adult 03 medical and health sciences 0302 clinical medicine Intervention (counseling) Internal medicine Cystitis Outpatients Quasi experimental study medicine Humans Antimicrobial stewardship 030212 general & internal medicine Practice Patterns Physicians' Medical diagnosis 0303 health sciences Duration of Therapy 030306 microbiology business.industry Medical record Middle Aged Anti-Bacterial Agents Ciprofloxacin Nitrofurantoin Urinary Tract Infections Female Guideline Adherence Family Practice business medicine.drug |
| Zdroj: | Family Practice. |
| ISSN: | 1460-2229 |
| DOI: | 10.1093/fampra/cmz068 |
| Popis: | Background Acute uncomplicated cystitis is one of the most common diagnoses for which antibiotic treatment is prescribed in the outpatient setting. Despite the availability of national guidelines, there remains a wide pattern in prescriber choices for therapy. Recent data portray a picture of consistently longer durations than recommended prescribed in outpatient settings. Objective The objective was to evaluate the effect of a system-based intervention on adherence to guideline-recommended durations of therapy for uncomplicated cystitis in the outpatient setting. Methods This quasi-experimental study included women aged 18–64 years who were seen at five family medicine clinics at an academic medical centre and were prescribed targeted antibiotics for uncomplicated cystitis (nitrofurantoin monohydrate/macrocrystals 100 mg, trimethoprim-sulfamethoxazole 160/800 mg or ciprofloxacin 250 mg). The intervention involved revising or adding pre-filled, but modifiable, default prescribing instructions in the electronic health record (EHR) for the targeted antibiotics. We evaluated adherence to guideline-recommended duration of therapy as well as days of therapy (DOT) before and after the intervention. Results A total of 787 pre-intervention and 862 post-intervention cases were included. Adherence to recommended duration of therapy increased from 29.4% to 76.3% (P < 0.01). The average DOT decreased by 23% from 6.6 to 5.1 (P < 0.01). Conclusion A stewardship intervention consisting of revising/adding default prescribing instructions to targeted antimicrobials in an EHR was associated with increased adherence to recommended durations of therapy for uncomplicated cystitis and reduction of unnecessary antibiotic exposure. More studies are needed to confirm effectiveness across multiple medical record platforms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|