Thromboinflammation in COVID-19 acute lung injury

Autor: William Beau Mitchell
Rok vydání: 2020
Předmět:
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Acute Lung Injury
Pneumonia
Viral
Autopsy
Review
Lung injury
Antithrombins
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Coagulopathy
Humans
Medicine
Pediatrics
Perinatology
and Child Health
030212 general & internal medicine
Platelet activation
Intensive care medicine
Pandemics
Inflammation
SARS-CoV-2
business.industry
Thrombin
COVID-19
Anticoagulants
Thrombosis
Blood Coagulation Disorders
Platelet Activation
medicine.disease
Capillaries
COVID-19 Drug Treatment
Pulmonary embolism
030228 respiratory system
Respiratory failure
Pediatrics
Perinatology and Child Health
Platelet aggregation inhibitor
Endothelium
Vascular
Coronavirus Infections
Pulmonary Embolism
business
Platelet Aggregation Inhibitors
Factor Xa Inhibitors
Zdroj: Paediatric Respiratory Reviews
ISSN: 1526-0542
Popis: Since the initial description in 2019, the novel coronavirus SARS-Cov-2 infection (COVID-19) pandemic has swept the globe. The most severe form of the disease presents with fever and shortness of breath, which rapidly deteriorates to respiratory failure and acute lung injury (ALI). COVID-19 also presents with a severe coagulopathy with a high rate of venous thromboembiolism. In addition, autopsy studies have revealed co-localized thrombosis and inflammation, which is the signature of thromboinflammation, within the pulmonary capillary vasculature. While the majority of published data is on adult patients, there are parallels to pediatric patients. In our experience as a COVID-19 epicenter, children and young adults do develop both the coagulopathy and the ALI of COVID-19. This review will discuss COVID-19 ALI from a hematological perspective with discussion of the distinct aspects of coagulation that are apparent in COVID-19. Current and potential interventions targeting the multiple thromboinflammatory mechanisms will be discussed.
Databáze: OpenAIRE
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