Combined Low-Frequency Ultrasound and Streptokinase Intravascular Destruction of Arterial Thrombi In Vivo
| Autor: | Vladimir Minchenya, Vyacheslav V. Dmitriev, I.E. Adzerikho, Alexander G. Mrochek, Anatoly I. Kulak |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Acoustics and Ultrasonics Ultrasonic Therapy medicine.medical_treatment Streptokinase Biophysics Fibrinogen Fibrin Dogs Internal medicine Angioplasty Fibrinolysis Animals Medicine Radiology Nuclear Medicine and imaging Thrombus Radiological and Ultrasound Technology biology Platelet-Rich Plasma business.industry Angiography Thrombosis medicine.disease Combined Modality Therapy Femoral Artery Coagulation Anesthesia biology.protein Cardiology Blood Coagulation Tests business medicine.drug |
| Zdroj: | Ultrasound in Medicine & Biology. 37:1644-1652 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2011.06.027 |
| Popis: | To prevent a distal embolization in the course of ultrasound (US) angioplasty, we combined US thrombus disruption in peripheral artery in vivo with simultaneous administration of streptokinase (SK). Acute thrombosis was induced in the femoral arteries of 23 dogs. Two hours after thrombus formation, thrombus destruction was performed using US (36 kHz) and by a combined US+SK (75,000 U/kg) administration. The results showed that thrombi were disrupted completely by 1.5 ± 0.5 min US. A combined US+SK action resulted in activation of fibrinolysis, as indicated by the increase in the content of fibrinogen and fibrin degradation products and D-dimers by a factor of 1.5–2.0 after 120 min from start of treatment compared with the SK lysis. The duration of clot destruction did not change; the distal embolization was not indicated; platelet aggregation activity dropped after thrombus destruction. In summary, intravascular thrombus destruction by a combined US and SK action in vivo is accompanied by enhancing the enzymatic fibrinolysis and lowering the platelet aggregation activity that assists in preventing the distal embolization of the resulting clot debris. |
| Databáze: | OpenAIRE |
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