Gender differences in the effects of antenatal betamethasone exposure on renal function in adult sheep
| Autor: | Lijun Tang, Nancy K. Valego, Mark C. Chappell, Philip Deibel, James C. Rose, Jianli Bi, Luke C. Carey, James Perrott, Xiurong Sun, Jorge P. Figueroa |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Aging medicine.medical_specialty Physiology Anti-Inflammatory Agents Natriuresis Hemodynamics Blood Pressure Gestational Age Kidney Betamethasone Sex Factors Pregnancy Physiology (medical) Internal medicine medicine Animals Infusions Intravenous Fetus Sheep business.industry Sodium Age Factors Gestational age medicine.disease Peptide Fragments Renal Plasma Flow Effective Proteinuria medicine.anatomical_structure Blood pressure Endocrinology Creatinine Prenatal Exposure Delayed Effects Renal blood flow Hypertension Potassium Female Angiotensin I business Developmental Physiology and Pregnancy Glomerular Filtration Rate medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R309-R317 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | Exposure to clinically relevant doses of glucocorticoids during fetal life increases blood pressure in adult male and female sheep. The purpose of this study was to evaluate the effects of prenatal exposure to betamethasone at 80–81 days of gestation on renal function in ewes and rams at 1.5 yr of age. In prenatal betamethasone-exposed males, compared with the vehicle-exposed animals, basal glomerular filtration rate (GFR) (1.93 ± 0.08 vs. 2.27 ± 0.10 ml·min−1·kg body wt−1) and the ability to excrete an acute Na+load (37.1 ± 4.4 vs. 53.7 ± 9.7%) were reduced. ( P < 0.03 and P = 0.03, respectively). In contrast, prenatal betamethasone exposure had no effect on basal GFR, Na+excretion, or the percentage of the Na+load excreted during the experiment in females. Systemic infusions of ANG-(1–7) at 9 ng·min−1·kg−1for 2 h had minimal effects on basal GFR, renal plasma flow, and Na+excretion in males but increased Na+excretion in females. However, the percentage of Na+load excreted during ANG-(1–7) infusion did not change in prenatal betamethasone-exposed females (113.1 ± 14.2 vs. 98.1 ± 12.2%) compared with the significant increase in vehicle females (139.2 ± 22.3 vs. 92.2 ± 7.5%) ( P = 0.01). The data indicate that antenatal betamethasone exposure produces gender-specific alternations in renal function and thus suggest that different mechanisms underlie the antenatal steroid-induced elevations in blood pressure in male and female offspring. |
| Databáze: | OpenAIRE |
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