Remobilization through stretching improves gait recovery in the rat
| Autor: | Julye Leiko Ywazaki, Anna Raquel Silveira Gomes, Paula Guilherme Ribeiro, Ana Claudia Mattiello-Sverzut, Vanessa Vilela Monte-Raso, Cibele M. Prado, L. O. Cação-Benedini |
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| Rok vydání: | 2013 |
| Předmět: |
Sarcomeres
medicine.medical_specialty Histology Passive stretching Sarcomere Hypokinesia Internal medicine Muscle Stretching Exercises Physical Conditioning Animal ALONGAMENTO medicine Animals Range of Motion Articular Rats Wistar Muscle Skeletal biology Chemistry Cell Biology General Medicine Anatomy Recovery of Function Gait Stifle Extracellular Matrix Fibronectins Rats Fibronectin Endocrinology medicine.anatomical_structure Hindlimb Suspension biology.protein Female Collagen Ankle medicine.symptom Range of motion Type I collagen |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Remobilization of a previously immobilized rat right hindlimb in the ankle plantar-flexion-shortened position by free movement alone or associated with intermittent passive stretching was assessed by analysis of gait variables and dorsiflexion range of motion. The variables were related with the expression of extracellular matrix proteins and the addition of serial sarcomeres. Sixty-four female Wistar rats were divided into 8 groups: immobilized, free for 10 days, immobilized/stretched/free for 1, 3 or 10 days, immobilized/free for 1, 3 or 10 days. Gait variables, range of motion, serial sarcomeres number, localization and staining intensity of fibronectin, and expressions of types I and III collagen were analyzed. The hypokinesia changed the functional variables of gait, reduced the dorsiflexion range of motion (ROM), increased the number of fibers with intracellular fibronectin/total number of fibers (FIF/TNF), and decreased the expression of the type I collagen. After three days, morphological changes were exacerbated and the number of serial sarcomeres was increased in both groups, immobilized/stretched/free and immobilized/free. Functional impairment, ROM restriction and increased FIF/TNF were also observed. Despite the above described alterations, 10 days of stretching program increased the effectiveness of remobilization leading to recovery of the abnormalities observed in the muscle. |
| Databáze: | OpenAIRE |
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