Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D
| Autor: | Luiza Ferreira Sperb, Juliano Soares Rabello Moreira, Luciana Verçoza Viana, Maria Elisa P. Muller, Thais Steemburgo, Tatiana Pedroso de Paula |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Ambulatory blood pressure Vitamina D lcsh:Medicine Blood Pressure Type 2 diabetes 030204 cardiovascular system & hematology Placebo Gastroenterology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pressão sanguínea Endocrinology Double-Blind Method Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine lcsh:Science Aged Cholecalciferol Multidisciplinary business.industry lcsh:R Health care Type 2 Diabetes Mellitus Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Vitamin D Deficiency Blood pressure Diabetes mellitus tipo 2 Treatment Outcome chemistry Diabetes Mellitus Type 2 Dietary Supplements Hypertension Female lcsh:Q Colecalciferol business Hipertensão |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| ISSN: | 2045-2322 |
| Popis: | Observational and experimental data reinforce the concept that vitamin D is associated with the pathogenesis of arterial hypertension. We investigated the effect of a single dose of 100,000 IU of cholecalciferol, in office blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM) in patients with type 2 diabetes mellitus (DM), hypertension, and hypovitaminosis D. Forty-three patients were randomized to a placebo or cholecalciferol group. BP was assessed by office measurements and 24-h ABPM, before and after intervention. At week 8, a greater decrease in median ABPM values was observed in cholecalciferol supplementation than in the placebo group for systolic 24-h (− 7.5 vs. − 1; P = 0.02), systolic daytime (− 7 vs. − 1; P = 0.007), systolic nighttime (− 7.0 vs. 3; P = 0.009), diastolic 24-h (− 3.5 vs. − 1; P = 0.037), and daytime DBP (− 5 vs. 0; P = 0.01). Office DBP was also reduced after vitamin D supplementation. A single dose of vitamin D3 improves BP in patients with type 2 diabetes, hypertension, and vitamin D insufficiency, regardless of vitamin D normalization. Vitamin D supplementation could be a valuable tool to treat patients with type 2 DM, hypertension, and hypovitaminosis D.Trial registration: Clinicaltrials.gov NCT 02204527. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |