Association of serum and follicular fluid leptin and ghrelin levels with in vitro fertilization success
| Autor: | Cengiz Kara, Funda Gode, Ahmet Zeki Işık, Kerem Enver Dirican, Okan Akın, Baris Büke, Ümit Göktolga, Seyit Temel Ceyhan, Süleyman Akarsu, Alper Başbuğ, Cem Korkmaz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Leptin medicine.medical_specialty Pregnancy Rate medicine.medical_treatment media_common.quotation_subject Fertilization in Vitro Intracytoplasmic sperm injection 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine medicine Humans Sperm Injections Intracytoplasmic reproductive and urinary physiology Menstrual cycle media_common 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry digestive oral and skin physiology Obstetrics and Gynecology medicine.disease Follicular fluid Ghrelin Follicular Fluid Pregnancy rate 030104 developmental biology Endocrinology clinical pregnancy Female business in vitro fertilization hormones hormone substitutes and hormone antagonists |
| Zdroj: | Ginekologia polska. 88(9) |
| ISSN: | 0017-0011 |
| Popis: | Dirican, Enver/0000-0001-6230-1229; Gode, Funda/0000-0002-9371-6942; Dirican, Enver/0000-0001-6230-1229 WOS: 000411999200002 PubMed: 29949336 Objectives: The aim of this study was to evaluate the relationship between in vitro fertilization (IVF) cycle outcomes, serum and follicular fluid (FF) levels of leptin and ghrelin. Material and methods: Forty-four women who underwent intracytoplasmic sperm injection cycles (ICSI) were enrolled in the study. On the third day (D3) of the menstrual cycle, venous blood samples were drawn for serum measurements of leptin and ghrelin. The follicular fluid (FF) and the corresponding oocyte were obtained from a single dominant preovulatory follicle at the time of oocyte pick-up. The FF and D3 serum leptin and ghrelin concentrations were measured by enzyme-linked immunosorbent assay. The relationship between pregnancy rate and serum, follicular fluid levels of leptin and ghrelin were analyzed. Results: Of the 44 cases included, nineteen achieved clinical pregnancy (43.18%). Follicular fluid ghrelin levels were significantly lower in the pregnant group than non-pregnant group (p < 0.05) With respect to FF leptin, there was no statistically significant differences between the pregnant and non-pregnant women (p > 0.05). There was no statistically significant difference in D3 serum ghrelin between pregnant and non-pregnant groups (p > 0.05). However, D3 serum leptin levels were significantly lower in pregnant women than non-pregnant women (p < 0.05). Conclusions: Lower ghrelin levels in the follicular fluid were associated with higher pregnancy rates. Also, D3 serum leptin levels were inversely correlated with clinical pregnancy rates. These findings support the potential role of these molecules on IVF outcomes. |
| Databáze: | OpenAIRE |
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