Modification of plasma glycosaminoglycans in long distance runners
| Autor: | Contini, M, Pacini, S, Ibba-Manneschi, L, Boddi, V, Ruggiero, M, Liguri, G, Gulisano, M, Catini, C, Mourao, P |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Keratan sulfate Physical Therapy Sports Therapy and Rehabilitation Running Glycosaminoglycan chemistry.chemical_compound Internal medicine medicine Humans Chondroitin Orthopedics and Sports Medicine Thromboembolic disease Life Style Glycosaminoglycans Long distance runners Total plasma Anthropometry Chondroitin Sulfates General Medicine Anatomy Keratan sulphate Endocrinology chemistry Keratan Sulfate Exercise Test Original Article Heparitin Sulfate Anaerobic exercise |
| Zdroj: | British Journal of Sports Medicine. 38:134-137 |
| ISSN: | 1473-0480 0306-3674 |
| DOI: | 10.1136/bjsm.2002.001388 |
| Popis: | Background:It is well documented that exercise reduces the risk of thromboembolic disease, possibly by increasing the plasma concentration of anticoagulant-antithrombotic compounds.Objectives:As plasma glycosaminoglycans (GAGs) play a role in the anticoagulant-antithrombotic potential of plasma, to examine the concentration and profile of these compounds in well trained, long distance runners and sedentary subjects.Methods:Plasma GAGs were measured in 10 male, long distance runners and 10 sedentary counterparts before and after ergometric tests. GAGs were extracted, purified, and identified by electrophoretic and enzymatic methods, and measured as hexosamine.Results:Plasma GAGs found in sedentary subjects were slow migrating heparan sulphates I and II, keratan sulphate I, and chondroitin 4–6-sulphate. Those found in trained athletes were slow migrating heparan sulphate I, chondroitin 4–6-sulphate (or keratan sulphate I), and fast migrating heparan sulphate. Total plasma concentrations of GAGs were higher in athletes than in sedentary subjects at rest. In sedentary subjects, plasma GAGs did not change after cycle ergometric exercise at 80% of their anaerobic threshold. However, the appearance of a novel band of heparan sulphate migrating faster than fast migrating heparan sulphate was observed in athletes after exercise.Conclusions:Exercise changes the amount and profile of plasma GAGs; these changes may play a role in protecting subjects who practise aerobic sports against developing cardiovascular disease. |
| Databáze: | OpenAIRE |
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