Autologous Platelet-Rich Fibrin (PRF) as an Adjunct in the Management of Osteoradionecrosis and Medication-Related Osteonecrosis of Jaws. Case Series in A Single Centre
| Autor: | Syed Nabil, Hui Yuh Soh, Abd Jabar Nazimi, Roszalina Ramli, Benjie Law, Rama Krsna Rajandram |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
bisphosphonate PRP Osteoradionecrosis medicine.medical_treatment ORN platelet-rich fibrin MRONJ lcsh:Technology Fibrin lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine jaw medicine osteoradionecrosis General Materials Science Autologous platelet Instrumentation lcsh:QH301-705.5 Fluid Flow and Transfer Processes biology business.industry lcsh:T Process Chemistry and Technology osteonecrosis General Engineering Soft tissue L-PRF 030206 dentistry Bisphosphonate medicine.disease Platelet-rich fibrin Adjunct lcsh:QC1-999 Computer Science Applications Surgery lcsh:Biology (General) lcsh:QD1-999 Sequestrectomy lcsh:TA1-2040 030220 oncology & carcinogenesis biology.protein business lcsh:Engineering (General). Civil engineering (General) lcsh:Physics PRF |
| Zdroj: | Applied Sciences Volume 11 Issue 8 Applied Sciences, Vol 11, Iss 3365, p 3365 (2021) |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app11083365 |
| Popis: | Osteoradionecrosis (ORN) of the jaws and medication-related osteonecrosis of the jaws (MRONJ) are uncommon but serious diseases affecting the oral and maxillofacial region with clinically similar appearance but distinct pathophysiology. Management of ORN and MRONJ is inherently challenging and the treatment outcomes are unpredictable. The use of autologous platelet concentrates (APCs) to promote hard and soft tissue healing is well described in the literature, and the efficacy of leucocyte and platelet-rich fibrin (L-PRF) has been well documented in a number of clinical studies. The aim of this study was to present our treatment strategy and the outcomes of incorporating L-PRF as a surgical adjunct in management of ORN and MRONJ in our centre. Methods: eight cases of ORN and MRONJ were treated with a combination of sequestrectomy and L-PRF as a surgical adjunct. Results: the overall success was 87.5%. Using L-PRF as an adjunct, we were able to predictably manage ORN and MRONJ without causing significant morbidity. Conclusion: our experience shows that L-PRF may be used as a valuable and cost-effective adjunct to surgical management of ORN and MRONJ. However, due to a limited number of patients, and a short period of review, the true effectiveness of the method is yet to be demonstrated in a longer follow-up study including a greater number of patients, besides the inclusion of a control group. |
| Databáze: | OpenAIRE |
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