Glutamine and regulation of gene expression in mammmalian cells. Special reference to phosphoenolpyruvate carboxykinase (PEPCK)
| Autor: | Sylvie Renouf, D. Meisse, Muriel Quillard, Alain Lavoinne, Annie Husson |
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| Rok vydání: | 1997 |
| Předmět: |
Glutamine
CHO Cells Polyenes Biology Biochemistry Gene Expression Regulation Enzymologic Phosphatidylinositol 3-Kinases chemistry.chemical_compound Cricetinae Gene expression Animals Humans Phosphatidylinositol Gene Cell Size Sirolimus Regulation of gene expression chemistry.chemical_classification General Medicine Water-Electrolyte Balance Actins Rats Amino acid Androstadienes Phosphotransferases (Alcohol Group Acceptor) Liver chemistry Phosphoenolpyruvate Carboxykinase (GTP) Signal transduction Wortmannin Phosphoenolpyruvate carboxykinase |
| Zdroj: | Biochimie. 79:125-128 |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/s0300-9084(97)81503-9 |
| Popis: | The repertoire of the actions of specific amino acids on gene expression is relatively limited in mammalian cells. Glutamine constitutes the most studied amino acid and recent works intended to demonstrate its mechanism of action on two genes: the β-actin and the phosphoenolpyruvate carboxykinase genes. From these studies, it appears that glutamine may regulate gene expression by, at least, two different mechanisms: one through the glutamine-induced cell swelling, and another through its intracellular metabolism. The involvement of phosphatidylinositol 3-kinase in the signaling pathway triggered by cell swelling is discussed. |
| Databáze: | OpenAIRE |
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