Changes in blood-brain barrier function modify the neuroendocrine response to circulating substances
| Autor: | Milan Vigas, Daniela Jezova, B. B. Johansson, Oprsalová Z |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Protamine sulfate Apomorphine Endocrinology Diabetes and Metabolism Peptide hormone Biology Blood–brain barrier Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Corticosterone Internal medicine medicine Animals Protamines Endocrine and Autonomic Systems Dopaminergic Rats Inbred Strains Domperidone Rats medicine.anatomical_structure chemistry Blood-Brain Barrier Glucocorticoid medicine.drug |
| Zdroj: | Neuroendocrinology. 49(4) |
| ISSN: | 0028-3835 |
| Popis: | It is known that various experimental, pathological and even physiological situations may be accompanied by transient increases in blood-brain barrier (BBB) permeability. The hypothesis that under such conditions the blood-borne substances can reach the active sites in the brain in concentrations high enough to influence central control of hormone release was verified in these studies. A suitable experimental model of BBB opening by protamine sulfate administration in conscious rats was introduced. Using this model it was shown that the dopaminergic blocker domperidone inhibited apomorphine-induced ACTH release if permeability of the BBB was increased, but not under normal conditions. It is suggested that the changes in BBB function can modify the neuroendocrine response also to other circulating substances and this may be an important, until now unconsidered phenomenon in neuroendocrine research. |
| Databáze: | OpenAIRE |
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