Concentrations of trace minerals in the spinal cord of horses with equine motor neuron disease
| Autor: | John F. Cummings, Thomas W. Cronin, John M. King, Hussni O. Mohammed, Evelyne Weber Polack, Milton Birch |
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| Rok vydání: | 2000 |
| Předmět: |
Chromium
Male inorganic chemicals medicine.medical_specialty Cord Iron Sodium Potassium Inorganic chemistry chemistry.chemical_element Spinal Cord Diseases Selenium Internal medicine medicine Animals Magnesium Horses Motor Neuron Disease Manganese Cadmium General Veterinary Phosphorus Mercury General Medicine Motor neuron Spinal cord Trace Elements Zinc Endocrinology medicine.anatomical_structure Lead Spinal Cord chemistry Inductively coupled plasma atomic emission spectroscopy Calcium Female Horse Diseases Copper Aluminum |
| Zdroj: | American Journal of Veterinary Research. 61:609-611 |
| ISSN: | 0002-9645 |
| Popis: | Objective—To compare concentrations of trace minerals in the spinal cord of horses with equine motor neuron disease (EMND) with those of horses without neurologic disease (control horses). Animals—24 horses with EMND and 22 control horses. Procedure—Spinal cord trace mineral concentrations in horses with EMND and control horses were analyzed by use of inductively coupled plasma atomic emission spectroscopy (calcium, phosphorus, sodium, potassium, magnesium, copper, iron, manganese, nickel, zinc, aluminum, cobalt, and chromium), atomic absorption spectrophotometry (lead and cadmium), flameless atomic absorption (mercury), and fluorometry (selenium). Results—Copper concentration was significantly higher in the spinal cord of horses with EMND, compared with control horses; spinal cord concentrations of all other trace minerals were similar between groups. Conclusion and Clinical Relevance—Among spinal cord trace minerals investigated in the study, only copper concentrations were significantly different between horses with EMND and horses without neurologic disease, which suggests that copper may be involved in the pathogenesis of EMND. An hypothesis of oxidative injury in this disease is supported by the finding of increased copper concentrations in the spinal cord and by low vitamin E concentrations reported by other researchers. (Am J Vet Res 2000; 61:609–611) |
| Databáze: | OpenAIRE |
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