Pathogenesis of Epizootic Hemorrhagic Disease. I. Blood Coagulation during Viral Infection
| Autor: | John G. Debbie, Melvin K. Abelseth |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Blood Platelets
Hemorrhagic Fevers Viral medicine.medical_treatment Splenectomy Fibrinogen Hemorrhagic disorder Pathogenesis medicine Animals Immunology and Allergy Platelet Epizootic hemorrhagic disease Blood Coagulation Prothrombin time Factor VIII Aspirin medicine.diagnostic_test Heparin Venoms business.industry Deer Drug Synergism Infectious Diseases Coagulation Immunology Prothrombin Time Blood Vessels Blood Coagulation Tests business medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 124:217-222 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/124.2.217 |
| Popis: | Studies of coagulation were performed on 11 whitetail deer experimentally infected with the virus of epizootic hemorrhagic disease (EHD). Results indicated a decrease in fibrinogen and the activity of Factor VIII late in the infection, possibly the result of their utilization in clotting. Reductions of numbers and function of platelets were reflected by abnormal Russell's viper-venom time tests in the absence of significant change in the one-stage prothrombin time. It is suggested that a combination of damage to vascular walls and abnormalities of platelets is involved in the pathogenesis of EHD. Neither splenectomy nor the dosages of heparin and aspirin administered altered the course of EHD infection in deer. |
| Databáze: | OpenAIRE |
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