Reduced renal function in patients with simple renal cysts
| Autor: | Michael A. Brumback, Deborah A. Baumgarten, Sammy Moghazi, W. Charles O'Neill, Jafar Al-Said |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Nephrology Pathology medicine.medical_specialty Adolescent Urology Renal function urologic and male genital diseases Kidney cysts Cystic kidney disease chemistry.chemical_compound Internal medicine parasitic diseases medicine Humans Multicystic Dysplastic Kidney Cyst Clinical significance Aged Aged 80 and over Creatinine acquired cystic kidney disease business.industry kidney cysts Age Factors Kidney Diseases Cystic Middle Aged medicine.disease age chemistry renal mass Female medicine.symptom business cystic kidney disease chronic kidney disease Kidney disease |
| Zdroj: | Kidney International. 65:2303-2308 |
| ISSN: | 0085-2538 |
| Popis: | Reduced renal function in patients with simple renal cysts. Background. Sporadic renal cysts not associated with genetic polycystic disorders are common and generally thought to be of no clinical significance. Since multiple cysts frequently develop in end-stage renal disease (ESRD), we tested the hypothesis that cysts that are solitary or few in number are an early mani- festation of reduced renal function. Methods. We evaluated 561 hospitalized patients who un- derwent contrast-enhanced, abdominal computed tomography (CT) and correlated clinical characteristics and parameters of renal function with the presence or absence of renal cysts. Results. Age ranged from 16 to 100 years, mean serum creati- nine concentration was 0.88 mg/dL (range 0.4 to 2.1 mg/dL), and mean estimated creatinine clearance was 94 mL/min/ 1.73 m 2 (range 22 to 218 mL/min/1.73 m 2 ). The presence of cysts was significantly correlated with older age (P < 0.001), higher serum creatinine concentration (P < 0.002), and lower estimated creatinine clearance (P < 0.001). In a multivariate analysis, including age and gender, estimated creatinine clear- ance still correlated with the presence of cysts (P = 0.009). When patients were grouped by age, estimated creatinine clear- ance correlated with cysts in patients |
| Databáze: | OpenAIRE |
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