Lung Density and Pulmonary Artery Diameter are Predictors of Pulmonary Hypertension in Systemic Sclerosis
| Autor: | Berend C. Stoel, Margreet E. Bakker, Anne A. Schouffoer, Maarten K. Ninaber, Suzanne E. van Wijngaarden, Lucia J.M. Kroft, Jeska K. de Vries Bouwstra, Jan Stolk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
lung density Adult Male medicine.medical_specialty Percentile systemic sclerosis Hypertension Pulmonary Hemodynamics Pulmonary Artery Sensitivity and Specificity pulmonary artery diameter 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine medicine.artery Internal medicine pulmonary hypertension medicine Humans Radiology Nuclear Medicine and imaging Lung Aged 030203 arthritis & rheumatology Scleroderma Systemic business.industry Interstitial lung disease computed tomography Organ Size respiratory system Middle Aged medicine.disease Pulmonary hypertension body regions medicine.anatomical_structure Pulmonary artery Cardiology Female business Densitometry Tomography X-Ray Computed Body mass index |
| Zdroj: | Journal of Thoracic Imaging, 32(6), 391-397 |
| ISSN: | 1536-0237 |
| Popis: | PURPOSE The aim was to evaluate computed tomography (CT)-measured pulmonary artery diameter (PAD) and lung density as predictors of pulmonary hypertension (PH) in subjects with systemic sclerosis (SSc). We compared these PAD values with normal values and between SSc subgroups with PH and/or interstitial lung disease (ILD). We investigated whether PAD predicts PH and whether lung densitometry, by using the 85th percentile density value (Perc85) as a measure for ILD, can predict PH. MATERIALS AND METHODS PAD and Perc85 were measured in axial CT scans and compared between 54 SSc and 76 control subjects. Four SSc subgroups were defined on the basis of PH (systolic PA pressure ≥35 mm Hg) and/or ILD (fibrosis score ≥7): PH-/ILD-, PH-/ILD+, PH+/ILD-, and PH+/ILD+. The association of PAD with age, body mass index, Perc85, lung function, and hemodynamic measures was investigated using univariate correlation along with the predictive value of these measures with respect to PH. RESULTS PAD in SSc was larger than that in controls (30.1±4.9 vs. 26.9±2.7 mm, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|