Methyl bromide causes DNA methylation in rats and mice but fails to induce somatic mutations in lambda lacZ transgenic mice

Autor: J.H.M. van Delft, Vassiliki Pletsa, M.J.S.T. Steenwinkel, Soterios A. Kyrtopoulos, Robert A. Baan
Přispěvatelé: Gezondheidsrisico Analyse en Toxicologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, Centraal Instituut voor Voedingsonderzoek TNO
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Male
Cancer Research
Mouse
6 o alkylguanine DNA alkyltransferase
Gene mutation
O6-Alkylguanine-DNA alkyltransferase
Rats
Sprague-Dawley
chemistry.chemical_compound
DNA Adducts
Mice
7 methylguanine
Priority journal
DNA methylation
Stomach
Methylation
Hydrocarbons
Brominated
Chemistry
Tissue distribution
Oncology
Lac Operon
O6-Methylguanine
Methylating agents
Female
Animal cell
6 o methylguanine
Alkyltransferase
Guanine
Transgene
Mice
Transgenic
Biology
O(6)-Methylguanine-DNA Methyltransferase
Transgenic mouse
DNA adduct
Mus musculus
Animals
Bone marrow
Animal experiment
Pesticides
Nutrition
N7-methylguanine
Dose-Response Relationship
Drug
Somatic mutation
Mutagenesis
O-6-methylguanine-DNA methyltransferase
DNA Methylation
Nonhuman
Molecular biology
6-O-Methylguanine
Rats
Pesticide
Methyl bromide
chemistry
Controlled study
Mutagens
Zdroj: Cancer Letters, 135(1), 21-27. Elsevier Ireland Ltd
Cancer Letters 135:1(Jan1999):21-27
Cancer Letters, 135, 21-27
Cancer Letters, 1, 135, 21-27
ISSN: 0304-3835
Popis: Laboratory of Chemical Carcinogenesis, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.Following single or multiple oral treatments of rats or lambda lacZ transgenic mice with methyl bromide, methylated DNA adducts (N7- and/or O6-methylguanine) were found at comparable levels in various tissues, including among others the glandular stomach, the forestomach and the liver. Multiple rat treatment resulted in substantial decreases in the repair enzyme O6-alkylguanine-DNA alkyltransferase which were probably due in part to direct interaction of the enzyme with methyl bromide. However, no induction of mutagenesis in the lacZ transgene could be detected in any tissue 14 days after single treatments of up to 50 mg/kg or after multiple treatments of as many as 10 daily treatments of 25 mg/kg MeBr.
Databáze: OpenAIRE
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