Genotypes of Candida albicans isolated from healthy individuals and their distribution in patients with oral candidiasis
| Autor: | Kazuo Shimozato, Toshio Kanbe, Yuki Takagi, Fumihiko Kawamoto, Hideo Fukano, Toshinobu Horii, Reiko Tanaka |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Microbiology (medical) Genotype biology Fungal genetics Case-control study biology.organism_classification Corpus albicans Microbiology Infectious Diseases Candidiasis Oral Case-Control Studies Oral microbiology Candida albicans Carrier State Humans Microsatellite Female Pharmacology (medical) Allele DNA Fungal Aged |
| Zdroj: | Journal of Infection and Chemotherapy. 19:1072-1079 |
| ISSN: | 1341-321X |
| Popis: | For the study of Candida albicans genotypes involved in development of candidiasis, Candida albicans isolates were collected from healthy volunteers and patients with oral candidiasis and genotyped on the basis of 25S rDNA and microsatellite polymorphisms. In the microsatellite analysis using two microsatellite markers (CDC3 and CAI), 63 healthy volunteer isolates were classified into 35 genotypes (allelic relations to CDC3 alleles 1:2/CAI alleles 1:2), among which genotypes II (115:119/23:23), III (115:123/18:27), and V (123:127/32:41) were found at frequencies of 12.7 %, 7.9 %, and 7.9 %, respectively. In 68 oral candidiasis isolates classified into 39 genotypes, genotypes II and III were identified in 4.4 % and 20.6 % of the isolates, respectively. The frequency of genotype III was higher in the candidiasis isolates than in the healthy isolates (p < 0.05). These results suggest that genotype III C. albicans assigned by CDC3/CAI is related to the development of oral candidiasis. |
| Databáze: | OpenAIRE |
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