Shape and volume changes of the superior lateral ventricle after electroconvulsive therapy measured with ultra-high field MRI
| Autor: | Iris E. C. Sommer, René C.W. Mandl, Jeroen C.W. Siero, Sophie M. Heringa, Jasper O. Nuninga, Metten Somers, Wendy Nieuwdorp, Marco P. Boks |
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| Přispěvatelé: | Spinoza Centre for Neuroimaging, Movement Disorder (MD), Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Rok vydání: | 2021 |
| Předmět: |
STIMULATION
medicine.medical_specialty SUBVENTRICULAR ZONE DISORDERS medicine.medical_treatment Neurogenesis Neuroscience (miscellaneous) Subventricular zone Stimulation ANGIOGENESIS NEUROBLASTS HIPPOCAMPAL NEUROGENESIS CELL-PROLIFERATION Lateral ventricles Electroconvulsive therapy Internal medicine Lateral Ventricles Neuroplasticity medicine Animals Humans Radiology Nuclear Medicine and imaging Electroconvulsive Therapy Mammals Neurons business.industry Dentate gyrus ECT GLOBAL BURDEN DEPRESSION Magnetic Resonance Imaging Shape analysis SEIZURES INCREASE Psychiatry and Mental health medicine.anatomical_structure nervous system Ventricle Cardiology business |
| Zdroj: | Psychiatry Research-Neuroimaging, 317. Elsevier Ireland Ltd Psychiatry research: Neuroimaging, 317:111384. ELSEVIER IRELAND LTD |
| ISSN: | 1872-7506 0925-4927 |
| Popis: | The subventricular zone (SVZ) of the lateral ventricles harbors neuronal stem cells in adult mammals. Rodent studies report neurogenic effects in the SVZ of electroconvulsive stimulation. We hypothesize that if this finding translates to depressed patients undergoing electroconvulsive therapy (ECT), this would be reflected in shape changes at the SVZ. Using T1-weighted MR images acquired at ultra-high field strength (7T), the shape and volume of the ventricles were compared from pre to post ECT after 10 ECT sessions (in patients twice weekly) or 5 weeks apart (controls) using linear mixed models with age and gender as covariates. Ventricle shape significantly changed and volume significantly decreased over time in patients for the left ventricle, but not in controls. The decrease in volume of the ventricles was associated to a decrease in depression scores, and an increase in the left dentate gyrus, However, the shape changes of the ventricles were not restricted to the neurogenic niche in the lateral walls of the ventricles, providing no clear evidence for neurogenesis as sole explanation of volume changes in the ventricles after ECT. |
| Databáze: | OpenAIRE |
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