Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians
| Autor: | Tony R. Merriman, Murray L. Barclay, Rebecca L. Roberts, Marc Ferrante, Isabelle Cleynen, Richard B. Gearry, Robert W Bentley, Severine Vermeire, Paul Rutgeerts |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Immunology Single-nucleotide polymorphism Genome-wide association study Disease Biology Zinc Finger Protein GLI1 Gastroenterology Inflammatory bowel disease White People Young Adult Risk Factors Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Genetics (clinical) Aged Crohn's disease Case-control study Odds ratio Middle Aged Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases Case-Control Studies Female Transcription Factors |
| Zdroj: | Genes & Immunity. 11:509-514 |
| ISSN: | 1476-5470 1466-4879 |
| Popis: | The transcription factor glioma-associated oncogene homolog 1 (GLI1) has a central function in gastrointestinal tract development and homeostasis. A non-synonymous single-nucleotide polymorphism (SNP) (rs2228226; Q1100E) in GLI1, which impairs GLI1 function in vitro, has been proposed as a risk factor for inflammatory bowel disease (IBD). In this study, we assessed the cumulative evidence for association of GLI1 with IBD. New genotype data for rs2228226 from New Zealand (907 controls, 990 IBD patients) and Belgian Caucasian case-control data sets (312 controls, 1214 IBD patients) were combined with data from the National Institute of Diabetes and Digestive and Kidney Diseases and three previously studied Caucasian case-control data sets. Meta-analysis of rs2228226 did not detect any association with ulcerative colitis (UC) (P=0.09, odds ratio (OR)=1.07, 95% confidence interval (CI)=0.92-1.24), Crohn's disease (CD) (P=0.29, OR=1.06, 95% CI=0.93-1.21) or overall IBD (P=0.15, OR=1.05, 95% CI=0.92-1.19). Our analyses of rs2228226 suggest that GLI1 is not a significant risk factor for IBD in Caucasians. |
| Databáze: | OpenAIRE |
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