When does Huntington's disease begin?
| Autor: | Elizabeth H. Aylward, Candace Young, Jason Brandt, Laura Krafft, Ann Marie Codori, Phillip R. Slavney, N G Ranen, Michael Magdalinski, Jeffrey R. Campodonico |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Disease Neuropsychological Tests Verbal learning Asymptomatic Basal Ganglia Huntington's disease Memory Presymptomatic Testing Medicine Humans Learning business.industry General Neuroscience Putamen Cognition medicine.disease Magnetic Resonance Imaging Cognitive test Neostriatum Psychiatry and Mental health Clinical Psychology Huntington Disease Female Neurology (clinical) medicine.symptom Atrophy business Psychomotor Performance |
| Zdroj: | Journal of the International Neuropsychological Society : JINS. 4(5) |
| ISSN: | 1355-6177 |
| Popis: | Recent studies have detected basal ganglia atrophy in clinically asymptomatic persons with the genetic mutation that causes Huntington's disease (HD). Whether reductions in caudate and putamen volume on MRI scans are associated with changes in cognitive and neurologic functioning was examined in 13 healthy adults with the IT-15 mutation. Reduced striatal volume was found to correlate with greater neurologic (largely motor) impairment, slower mental processing speed, and poorer verbal learning, although none of the participants met even liberal criteria for clinical diagnosis of HD. These correlations are strikingly similar to those observed in symptomatic HD patients, possibly reflecting the earliest manifestations of disease. ( JINS , 1998, 4 , 467–473.) |
| Databáze: | OpenAIRE |
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