Association between rheumatic diseases and cancer: results from a clinical practice cohort study
| Autor: | Serena Favretto, Enrico Boggio, Mario Pirisi, G. Guaschino, R. Bonometti, Mattia Bellan, Daniele Sola, Pier Paolo Sainaghi, Antonello Gibbin, Alessandro Gualerzi, Roberta Pedrazzoli |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty Paraneoplastic Syndromes education Polymyositis Polymyalgia rheumatica Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Neoplasms Rheumatic Diseases Internal Medicine medicine Humans Genetic Association Studies Aged 030203 arthritis & rheumatology Aged 80 and over business.industry Cancer Odds ratio Dermatomyositis medicine.disease Italy 030220 oncology & carcinogenesis Multivariate Analysis Emergency Medicine Physical therapy Population study Female Vasculitis business Precancerous Conditions Cohort study |
| Zdroj: | Internal and emergency medicine. 12(5) |
| ISSN: | 1970-9366 |
| Popis: | The association between cancer and immune-mediated rheumatic conditions is controversial, especially as far as polymyalgia rheumatica (PMR) is concerned. Furthermore, no clinical feature has been shown to be suggestive of a paraneoplastic rheumatic syndrome. With the present study, we aim to address both these issues. The study population comprised N = 1750 patients, including N = 100 with PMR, who attended our tertiary immuno-rheumatology clinic between January 1, 2005 and November 30, 2012. A rheumatic disease was deemed paraneoplastic if cancer had been diagnosed in the 2 years preceding or following its onset. The probability of a significant association between a specific rheumatic disease and cancer was evaluated by computing the odds ratio (OR): N = 702 patients with osteoarthritis serving as controls. Furthermore, clinical features distinguishing paraneoplastic rheumatic diseases were searched for by univariate and multivariate analysis. Sjogren’s syndrome (SS) [OR 3.6 (CI 95% 1.7–7.5)], PMR (OR 5.1 CI 95% 2.9–8.9), dermatomyositis/polymyositis [OR 12.09 (CI 95% 2.6–55.8)] and vasculitis [OR 3.70 (CI 95% 1.81–7.52)] are associated with cancer. At multivariate analysis, older age is associated with cancer among SS patients (p = 0.03), while in the PMR group, older age, male gender, and ≥6 tender joints are independent predictors of paraneoplastic PMR (p |
| Databáze: | OpenAIRE |
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