Reduced susceptibility to co-amoxiclav in Escherichia coli, Salmonella typhimurium and Klebsiella pneumoniae isolated in Romania between 1985 and 1993
| Autor: | R Gheorghiu, F Espinasse, Antonia Poiată, Marie-Hélène Nicolas-Chanoine, R Labia |
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| Rok vydání: | 1997 |
| Předmět: |
Salmonella typhimurium
Microbiology (medical) Salmonella Klebsiella pneumoniae medicine.medical_treatment Microbial Sensitivity Tests Amoxicillin-Potassium Clavulanate Combination medicine.disease_cause beta-Lactamases Microbiology Clavulanic Acids Clavulanic acid Escherichia coli medicine Humans Pharmacology (medical) Escherichia coli Infections Antibacterial agent Pharmacology biology Romania Amoxicillin biology.organism_classification Enterobacteriaceae Klebsiella Infections Infectious Diseases Salmonella Infections Beta-lactamase Drug Therapy Combination Isoelectric Focusing Bacteria Plasmids medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 39:103-106 |
| ISSN: | 1460-2091 |
| Popis: | By determining the beta-lactam susceptibility of Enterobacteriaceae isolated in Eastern Romania from 1985 to 1993, three Escherichia coli, three Salmonella typhimurium and one Klebsiella pneumoniae isolates with reduced susceptibility to co-amoxiclav were found. The antibiotic susceptibility of the isolates and their E. coli derivatives, and kinetic values suggested the following resistance mechanisms: hyperproduction of TEM in S. typhimurium, limited antibiotic uptake in K. pneumoniae and OXA production in one strain of E. coli. Despite a normal beta-lactamase activity, the two remaining E. coli strains and their derivatives were less susceptible to co-amoxiclav. |
| Databáze: | OpenAIRE |
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