Cognitive changes and brain connectomes, endocrine status, and risk genotypes in testicular cancer patients–A prospective controlled study
| Autor: | Sm Hadi Hosseini, Claus Højbjerg Gravholt, Mads Agerbæk, Robert Zachariae, Ali Amidi, Cecilie R. Buskbjerg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Apolipoprotein E Oncology Cancer Research medicine.medical_specialty Neuropsychological Tests survival Young Adult Cognition Testicular Neoplasms Internal medicine Testis Connectome medicine Humans Cognitive Dysfunction Testosterone Radiology Nuclear Medicine and imaging Prospective Studies Orchiectomy Cognitive decline RC254-282 Research Articles Testicular cancer medicine.diagnostic_test business.industry genetic variants Neoplasms. Tumors. Oncology. Including cancer and carcinogens Clinical Cancer Research Brain Neuropsychological test Middle Aged medicine.disease Magnetic Resonance Imaging Healthy Volunteers clinical cancer research Receptors Androgen Case-Control Studies urological oncology sense organs Verbal memory business Research Article |
| Zdroj: | Buskbjerg, C R, Amidi, A, Agerbaek, M, Gravholt, C H, Hosseini, SM H & Zachariae, R 2021, ' Cognitive changes and brain connectomes, endocrine status, and risk genotypes in testicular cancer patients–A prospective controlled study ', Cancer Medicine, vol. 10, no. 18, pp. 6249-6260 . https://doi.org/10.1002/cam4.4165 Cancer Medicine Cancer Medicine, Vol 10, Iss 18, Pp 6249-6260 (2021) |
| Popis: | Objective Previous research has indicated cognitive decline (CD) among testicular cancer patients (TCPs), even in the absence of chemotherapy, but little is known about the underlying pathophysiology. The present study assessed changes in cognitive functions and structural brain connectomes in TCPs and explored the associations between cognitive changes and endocrine status and hypothesized risk genotypes. Methods Thirty‐eight newly orchiectomized TCPs and 21 healthy controls (HCs) comparable to TCPs in terms of age and years of education underwent neuropsychological testing, structural MRI, and a biological assessment at baseline and 6 months later. Cognitive change was assessed with a neuropsychological test battery and determined using a standardized regression‐based approach, with substantial change defined as z‐scores ≤−1.64 or ≥1.64. MRI scans and graph theory were used to evaluate changes in structural brain connectomes. The associations of cognitive changes with testosterone levels, androgen receptor gene (AR) CAG repeat length, and genotypes (APOE, COMT, and BDNF) were explored. Results Compared with HCs, TCPs showed higher rates of substantial decline on processing speed and visuospatial ability and higher rates of substantial improvement on verbal recall and visuospatial learning (p The present study confirms previous findings of domain‐specific cognitive decline in testicular cancer patients following orchiectomy, but also points to domain‐specific improvements. The results do not indicate changes in brain connectomes or endocrine status to be the main drivers of cognitive changes. |
| Databáze: | OpenAIRE |
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