Oral contraceptive use and genital anomalies in sons. A Danish cohort study
| Autor: | Andreas Ernst, Linn Håkonsen Arendt, LE Buur, Cecilia Høst Ramlau-Hansen, Jørn Olsen, A-M Nybo Andersen, VR Laurberg |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Denmark Population 010501 environmental sciences Toxicology 01 natural sciences Nuclear Family Congenital abnormalities Cohort Studies Danish 03 medical and health sciences Pregnancy Cryptorchidism medicine Humans education 030304 developmental biology 0105 earth and related environmental sciences Hypospadias 0303 health sciences education.field_of_study Oral contraceptives business.industry Obstetrics Infant Odds ratio medicine.disease language.human_language Logistic Models Contraceptive use Maternal Exposure Prenatal Exposure Delayed Effects Multivariate Analysis language Female business Contraceptives Oral Hormone Cohort study |
| Zdroj: | Buur, L E, Laurberg, V R, Ernst, A, Arendt, L H, Nybo Andersen, A M, Olsen, J & Ramlau-Hansen, C H 2019, ' Oral contraceptive use and genital anomalies in sons : A Danish cohort study ', Reproductive Toxicology, vol. 89, pp. 67-73 . https://doi.org/10.1016/j.reprotox.2019.07.004 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2019.07.004 |
| Popis: | Exposure to exogenous sex hormones with estrogenic or anti-androgen properties may influence intrauterine development of male genitals. This population-based cohort study based on data from 44,408 live-born singleton sons in the Danish National Birth Cohort (DNBC) aimed to investigate whether maternal use of oral contraceptives prior to or during early pregnancy increase the risk of cryptorchidism or hypospadias. We found no consistent association between use of oral contraceptives and cryptorchidism or hypospadias, neither in those exposed any time four months prior to conception [cryptorchidism: adjusted Odds Ratio (aOR): 1.06 (95% CI: 0.91; 1.23), hypospadias: 0.74 (95% CI: 0.53; 1.03)] nor in those exposed any time during the first trimester of pregnancy [cryptorchidism: aOR: 0.93 (95% CI: 0.53; 1.62), hypospadias: 1.02 (95% CI: 0.32; 3.23)]. Despite relatively strong exposure levels from oral contraceptive use in pregnancy, this study revealed no evidence of an increased risk of either two genital malformations. |
| Databáze: | OpenAIRE |
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