Antiparasitic effect of the Psidium guajava L. (guava) and Psidium brownianum MART. EX DC. (araçá-de-veado) extracts
Autor: | Fábia F. Campina, Miriam Rolón, Antonio Judson Targino Machado, Henrique Douglas Melo Coutinho, Maria A. Freitas, Camila Fonseca Bezerra, Rafael Pereira da Cruz, Maria do Socorro Costa, Antonia Thassya Lucas dos Santos, Antonio Linkoln Alves Borges Leal, Cathia Coronel, Maria Flaviana Bezerra Morais-Braga, Celeste Vega Gómez, Gioconda Morais de Andrade Bezerra Martins, Joara Nályda Pereira Carneiro |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.drug_class Antiparasitic Trypanosoma cruzi 030106 microbiology 030231 tropical medicine Decoction Toxicology Leishmania braziliensis Cell Line Mice 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Animals Leishmania infantum Cytotoxicity Psidium Antiparasitic Agents biology Traditional medicine Plant Extracts Chemistry Low activity General Medicine biology.organism_classification Plant Leaves Antiprotozoal Food Science |
Zdroj: | Food and Chemical Toxicology. 119:275-280 |
ISSN: | 0278-6915 |
Popis: | In the search for new therapeutic agents against neglected diseases, both aqueous and hydroethanolic extracts from Psidium guajava L. and P. brownianum Mart ex DC leaves were investigated regarding their antiparasitic effect and cytotoxic potential. The extracts were tested at three concentrations (250, 500 and 1000 μg/mL) against Trypanosoma cruzi epimastigote forms (Chagas, 1909), Leishmania braziliensis (Vianna, 1911) and L. infantum promastigotes forms (Nicolle, 1908), as well as against fibroblasts. P. guajava showed no activity against T. cruzi forms, while the hydroethanolic (PBHE), aqueous by decoction (PBAED) and aqueous by infusion (PBAEI) P. browninaum extracts were responsible, respectively, for inhibiting 100, 100 and 92.68% of T. cruzi epimastigote growth at the 1000 μg/mL concentration. The P. brownianum hydroethanolic extract (PBHE) at the highest concentration caused 58.46% death in L. braziliensis, thus demonstrating moderate activity, however when tested against L. infantum, the PBHE inhibited their growth by 37.16%, revealing its low activity. As for the cytotoxicity assays, the P. brownianum aqueous extract by decoction (PBAED) obtained the highest death percentage when compared to the others, causing 90.85% fibroblast mortality at the 1000 μg/mL concentration. |
Databáze: | OpenAIRE |
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