Obesity and clinical severity in patients with COVID-19: a scoping review protocol

Autor: Francismayne Batista Santana, Marcela Larissa Costa, Marco Antônio Prado Nunes, Dayane Franciely Conceição Santos, Laís Santos Costa, Edilene Fernandes Nonato, Jessyca Teles Barreto, Tamila das Neves Ferreira, Márcia Ferreira Cândido de Souza, Giselle dos Santos Dias, Raquel Simões Mendes-Netto, Jeniffer Santos Santana, Tereza Virgínia Silva Bezerra do Nascimento, Ana Caroline Cardoso Silva, Maria Carolina Barros Costa, Carlos Adriano Santos Souza
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Systematic Reviews, Vol 10, Iss 1, Pp 1-6 (2021)
Systematic Reviews
ISSN: 2046-4053
Popis: Background Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, developing acute respiratory failure and other serious complications, especially in older individuals and people with obesity and comorbidities. Thus, obese patients tend to have a more severe course of COVID-19. Thus, this review aims to synthesize the evidence in the literature that associates COVID-19 and the severity of clinical outcomes in infected obese patients. Methods This protocol was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols Statement. Scientific and gray literature will be systematically selected from PubMed/MEDLINE, Latin American Literature in Health Sciences, Online Scientific Electronic Library, Scopus, ScienceDirect, Web of Science, Embase, and Cochrane. The selection of articles will be limited to studies published in English, Portuguese, and Spanish from December 2019 onwards. The main clinical outcomes will be clinical severity in obese patients with COVID-19 as tachypnea (respiratory rate, ≥ 30 breaths per minute), hypoxemia (oxygen saturation, ≤ 93%), the ratio of the partial pressure of arterial oxygen to fraction of inspired oxygen ( 50% of the lung field involved within 24–48 h), diagnosis of the severe acute respiratory syndrome, need of invasive mechanical ventilation, and mortality. Two reviewers will independently screen all citations, full-text articles, and abstract data. Selection bias will be minimized by excluding studies published before December 2019. Conflicts will be resolved through a third reviewer and consensus-building. Moreover, findings will be reported using narrative synthesis and tabulation of the summaries. Discussion Given the need for early detection of the possible implications and treatment for patients with obesity diagnosed with COVID-19, the scoping review will be useful to capture the state of the current literature, identify the gaps, and make recommendations for future research for directing the conduct and optimization of therapies in these patients by the multiprofessional teams. Systematic review registration Open Science Framework: https://osf.io/xrkec
Databáze: OpenAIRE
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