Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis from HIV-infected Patients Undergoing Highly Active Antiretroviral Therapy
| Autor: | Luciana Armada, Lucio Souza Gonçalves, Tulio G. V. Gama, Fábio Ramôa Pires |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Pathology CD3 Complex T-Lymphocytes Periapical Granuloma HIV Infections CD8-Positive T-Lymphocytes 0302 clinical medicine Antiretroviral Therapy Highly Active Fisher's exact test CD20 biology Smoking Interleukin-18 virus diseases Middle Aged Immunohistochemistry CD4 Antigens symbols Interleukin 18 Female Brazil Adult medicine.medical_specialty Periapical cyst Antigens Differentiation Myelomonocytic 03 medical and health sciences symbols.namesake Interferon-gamma Antigens CD medicine Humans General Dentistry Aged Radicular Cyst Periapical periodontitis business.industry Interleukin-6 Tumor Necrosis Factor-alpha 030206 dentistry medicine.disease Antigens CD20 030104 developmental biology biology.protein business CD8 Biomarkers Periapical Periodontitis |
| Zdroj: | Journal of endodontics. 42(6) |
| ISSN: | 1878-3554 |
| Popis: | Introduction This study tested the hypothesis that the inflammatory cell profile (CD3-, CD4-, CD8-, CD20-, and CD68-positive cells) and the expression of immunologic markers (tumor necrosis factor α, interferon-γ, interleukin-6, and interleukin-18) in chronic apical periodontitis are the same between non–HIV-infected patients and HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Methods Thirty-four surgically excised chronic apical periodontitis lesions were sampled from 34 patients (17 HIV-infected and 17 non–HIV-infected). The lesions were extracted from teeth with no previous endodontic treatment. All HIV-infected patients were undergoing HAART. The specimens were submitted to histopathologic and immunohistochemical analyses by using an optical microscope. Immunoexpression was graded into 2 levels, focal to weak and moderate to strong. The χ 2 , Fisher exact, and Mann-Whitney tests were used to analyze all significant differences between groups. Results Periapical cysts represented 70.6% and 52.9% of the lesions in the HIV-infected and non–HIV-infected groups, respectively; however, no statistically significant difference was observed ( P = .481). There were no statistically significant differences between groups for the inflammatory cell profile and for any of the immunologic markers ( P > .05). Conclusions There are no statistically significant differences of the cellular profile and expression of immunologic markers in chronic apical periodontitis between non–HIV-infected patients and HIV-infected patients undergoing HAART. |
| Databáze: | OpenAIRE |
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