Spectrum ofFusariuminfections in tropical dermatology evidenced by multilocus sequencing typing diagnostics
| Autor: | M. Sudhadham, Sumanas Bunyaratavej, Anne D. van Diepeningen, G. Sybren de Hoog, Sarah A. Ahmed, Peiying Feng |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Fusarium Fusariosis Species complex Genotyping Techniques Dermatology Biology Microbiology Peptide Elongation Factor 1 Onychomycosis Genetic variation Fusarium oxysporum medicine Dermatomycoses Humans Typing Internal transcribed spacer Phylogeny Genetic diversity Tinea Pedis food and beverages General Medicine Thailand biology.organism_classification medicine.disease Infectious Diseases Female Multilocus Sequence Typing |
| Zdroj: | Mycoses, 58(1), 48-57. John Wiley and Sons Ltd |
| ISSN: | 0933-7407 |
| DOI: | 10.1111/myc.12273 |
| Popis: | Fusarium species are emerging causative agents of superficial, cutaneous and systemic human infections. In a study of the prevalence and genetic diversity of 464 fungal isolates from a dermatological ward in Thailand, 44 strains (9.5%) proved to belong to the genus Fusarium. Species identification was based on sequencing a portion of translation elongation factor 1-alpha (tef1-α), rDNA internal transcribed spacer and RNA-dependent polymerase subunit II (rpb2). Our results revealed that 37 isolates (84%) belonged to the Fusarium solani species complex (FSSC), one strain matched with Fusarium oxysporum (FOSC) complex 33, while six others belonged to the Fusarium incarnatum-equiseti species complex. Within the FSSC two predominant clusters represented Fusarium falciforme and recently described F. keratoplasticum. No gender differences in susceptibility to Fusarium were noted, but infections on the right side of the body prevailed. Eighty-nine per cent of the Fusarium isolates were involved in onychomycosis, while the remaining ones caused paronychia or severe tinea pedis. Comparing literature data, superficial infections by FSSC appear to be prevalent in Asia and Latin America, whereas FOSC is more common in Europe. The available data suggest that Fusarium is a common opportunistic human pathogens in tropical areas and has significant genetic variation worldwide. |
| Databáze: | OpenAIRE |
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