Comparative Study of Interleukin-1β Expression by Peripheral Blood Mononuclear Cells and Purified Monocytes Experimentally Infected withBurkholderia pseudomalleiandBurkholderia thailandensis

Autor:	Puntharee Butkhamchot, Sutatip Pongcharoen, Pannika R. Niumsup
Rok vydání:	2008
Předmět:	Burkholderia pseudomallei Melioidosis Burkholderia Interleukin-1beta Immunology Virulence Peripheral blood mononuclear cell Monocytes Protein expression Microbiology medicine Humans RNA Messenger Cells Cultured Messenger RNA Burkholderia thailandensis biology General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification medicine.disease Virology Interleukin 1β Leukocytes Mononuclear bacteria
Zdroj:	Immunological Investigations. 37:704-713
ISSN:	1532-4311 0882-0139
DOI:	10.1080/08820130802307310
Popis:	Burkholderia pseudomallei is a causative agent of melioidosis. The present study investigated IL-1beta mRNA and protein expression by peripheral blood mononuclear cells and purified monocytes (n = 10) in response to infection with B. pseudomallei and B. thailandensis. Similarly increased IL-1beta mRNA and protein expression was found in both PBMC and purified monocytes stimulated with B. pseudomallei and B. thailandensis. Thus, this study suggests that IL-1beta response does not differ between infections with B. pseudomallei and its non-virulent counterpart and other mechanisms may be involved in their distinct virulence in causing the disease.
Databáze:	OpenAIRE
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