Topical treatment of rhinosinusitis
| Autor: | Luigi Terracciano, L Bernardo, Alessandro Fiocchi, Daniele Giovanni Ghiglioni, Gabriel R. Bouygue, Teresita Sarratud |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents medicine.drug_class Administration Topical medicine.medical_treatment Immunology MEDLINE Adrenal Cortex Hormones medicine Humans Immunology and Allergy Sinusitis Child Intensive care medicine Saline Rhinitis Antibacterial agent Clinical Trials as Topic business.industry medicine.disease Surgery Nasal decongestant Clinical trial Decongestant Nasal Decongestants Child Preschool Pediatrics Perinatology and Child Health Histamine H1 Antagonists Antihistamine business |
| Zdroj: | Pediatric Allergy and Immunology. 18:62-67 |
| ISSN: | 1399-3038 0905-6157 |
| DOI: | 10.1111/j.1399-3038.2007.00637.x |
| Popis: | We reviewed current clinical evidence for the use of topical treatments in pediatric rhinosinusitis. Repeated Entrez PubMed searches were done using the template algorithm [rhinosinusitis AND (...)] with the settings: [Humans; English; All Child 0-18; Clinical trial; Last 10 yr] for the following comparators: steroid, irrigation, saline, antihistamine, decongestant, antibiotic, antimycotic, fungicide. The authors' clinical experience in the pediatric allergy unit of a university hospital was also drawn upon. Pediatric studies were retrieved but only one satisfied current evidence-based medicine standards for reporting clinical trials. Studies could not be systematized because of methodological, analytical, and interpretation biases. While saline irrigation, nasal decongestants, steroids, antibiotics, antihistamines and fungicides are all in widespread pediatric use, comparing studies from the literature for evidence of efficacy implied subjective appraisal, except in the case of topical steroids. Evidence for the efficacy of topical treatment for pediatric rhinosinusitis is narrative albeit this modality cannot be excluded from individualized patient protocols on the basis of the clinical literature alone. With the exception of topical steroids, no weighable evidence of effectiveness supports the premise that topical treatments actually serve the purpose for which they are widely prescribed in pediatrics. |
| Databáze: | OpenAIRE |
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