Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females

Autor: Ahmed Salah El-Din Tork, Tamer A. Hosny, Kiyoshi Ichihara, Rania Nabil Bedair, Eman Ahmed El-Attar
Rok vydání: 2021
Předmět:
Anti-Mullerian Hormone
endocrine system diseases
Physiology
Nervous System
Epithelium
Male infertility
0302 clinical medicine
Animal Cells
Female Infertility
Medicine and Health Sciences
Unexplained Infertility
030212 general & internal medicine
Ovarian Reserve
Unexplained infertility
media_common
education.field_of_study
030219 obstetrics & reproductive medicine
Multidisciplinary
biology
Female infertility
Age Factors
Anti-Müllerian hormone
Middle Aged
Healthy Volunteers
Oncology
OVA
Pituitary Gland
Medicine
Egypt
Female
Cellular Types
Anatomy
hormones
hormone substitutes
and hormone antagonists
Research Article
Polycystic Ovary Syndrome
Adult
endocrine system
Adolescent
Urology
Science
media_common.quotation_subject
Population
Endocrine System
Fertility
Young Adult
03 medical and health sciences
medicine
Humans
Male Infertility
education
Ovarian reserve
Granulosa Cells
urogenital system
business.industry
Cancers and Neoplasms
Biology and Life Sciences
Epithelial Cells
Cell Biology
Nomogram
medicine.disease
Nomograms
Neuroanatomy
Germ Cells
Biological Tissue
Age Groups
Infertility
People and Places
Oocytes
biology.protein
Women's Health
Population Groupings
Lutein Cells
business
Gynecological Tumors
Neuroscience
Zdroj: PLoS ONE, Vol 16, Iss 7, p e0254858 (2021)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0254858
Popis: BackgroundAnti-Müllerian hormone (AMH) is an important determinant of ovarian reserve in fertility workups in many clinical settings. Thus, we investigated the age dependent decline in AMH specific to the Egyptian population and sought to establish an age dependent reference interval parametrically.MethodsSerum samples were collected from 841 apparently healthy women. AMH was measured using an electro-chemiluminescent technique. Box-Cox power transformation was used to make the AMH distribution Gaussian for parametric derivation of reference intervals.ResultsPower of 0.4 was found optimal for Gaussian transformation of AMH reference values. We demonstrate the strong negative relation between circulating AMH and female age with Spearman’s correlation coefficient of rS= −0.528. Age-specific reference interval was determined for every 5 years of age from 16 to 49, and nomogram was constructed by smoothing the lines connecting adjacent lower and upper reference limits.ConclusionThe age-specific reference intervals and the age-AMH nomogram could be valuable in the clinical practice of in reproductive medicine. To our knowledge, this is the first study to confirm AMH levels in Egyptian females. We were able to explore age-related AMH levels specific to Egyptian females in the fertile age group and to treat skewed AMH data in a multi-step scheme using power transformation. Thus, a more accurate nomogram was constructed accommodating a profile delineated for a wide age range and a rescaled AMH axis improving its usability.
Databáze: OpenAIRE
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