Role of HLA in congenital heart block: susceptibility alleles in mothers
| Autor: | Saija Koskimies, Sirén Mk, Kurki P, Risto Kaaja, Julkunen H |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Heart block
Genes MHC Class II Genes MHC Class I Human leukocyte antigen 030204 cardiovascular system & hematology Asymptomatic 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology Antigen Gene Frequency Medicine Humans Genetic Predisposition to Disease Allele Allele frequency Alleles 030203 arthritis & rheumatology biology business.industry Infant Newborn Chromosome Mapping medicine.disease Heart Block Antibodies Antinuclear Immunology biology.protein Female medicine.symptom Antibody business |
| Zdroj: | Lupus. 8(1) |
| ISSN: | 0961-2033 |
| Popis: | In congenital heart block (CHB), abnormal maternal immunisation leads to autoantibody production against SS-A/Ro and SS-B/La antigens. These maternal antibodies are transferred across the placenta to the unborn child and are believed to transmit irreversible immunological injury in developing foetal heart tissue, thus causing 3rd-degree atrioventricular block. The mothers may suffer from systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (SS), but they may be asymptomatic. Women with primary SS show a typical autoimmune HLA antigen pattern, namely higher frequency of HLA B8 and DR3 than in the normal population. The HLA pattern may affect individual ability to resist infecting bacteria and viruses and to response in various ways to autoantigens. It is probable that other factors such as genetic regulation of immune response are involved in CHB. We compared the HLA class I and class II alleles of mothers having CHB children with those of women suffering from primary SS and having healthy children, and with those of healthy Finns. Antibodies against 52-kD and 60-kD SS-A/Ro and 48-kD SS-B/La antigens were compared between the two groups of mothers. Our results show that anti-SS-A/Ro antibodypositive mothers all show a strong association with known autoimmune-predisposing HLA alleles, however, the mothers of CHB children differ in some HLA class I alleles, and especially in HLA haplotypes, from mothers of healthy children. Mothers with HLA A1, Cw7, B8 and without B15 are at particularly high risk of having CHB children. |
| Databáze: | OpenAIRE |
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