Thinness at Birth and Glucose Tolerance in Seven-year-old Children
| Autor: | A. W. Shiell, G. S. Gordon, C. M. Law, D. J. P. Barker, C. N. Hales |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism Birth weight Type 2 diabetes Impaired glucose tolerance Endocrinology Thinness Risk Factors Diabetes mellitus Internal medicine Glucose Intolerance Internal Medicine medicine Birth Weight Humans Longitudinal Studies Child Glucose tolerance test medicine.diagnostic_test business.industry Body Weight Infant Newborn Glucose Tolerance Test Infant Low Birth Weight medicine.disease Confidence interval Low birth weight Diabetes Mellitus Type 2 Regression Analysis Gestation medicine.symptom business |
| Zdroj: | Diabetic Medicine. 12:24-29 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.1995.tb02057.x |
| Popis: | Adults who had low birthweight and were thin at birth have an increased risk of Type 2 diabetes and impaired glucose tolerance. To discover whether thinness at birth is associated with reduced glucose tolerance in children, 250 7-year-old children underwent an abbreviated oral glucose tolerance test. Children who were thin at birth, as measured by a low ponderal index (birthweight length-3) had higher plasma glucose concentrations. Plasma glucose concentration 30 min after a glucose load rose by 0.07 mmol l-1 (95% confidence interval 0.00 to 0.14; p = 0.04) for every unit (kg m-3) fall in ponderal index. Children in the lowest quarter of the distribution of ponderal index (23 kg m-3 or less) had a mean 30 min plasma glucose concentration of 8.49 mmol l-1 compared to a mean of 7.97 mmol l-1 for those in the highest quarter (> 27.5 kg m-3). These associations were independent of duration of gestation, gender, social class or the child's current weight. This is consistent with the hypothesis that Type 2 diabetes originates in utero. |
| Databáze: | OpenAIRE |
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