Absorption, distribution and elimination of fumonisin B1 metabolites in weaned piglets
| Autor: | Mária Weber, Roland Pósa, Péter Horn, Melinda Kovács, Johann Bauer, Rene Mamet, Miklós Mézes, Judit Fodor, Krisztián Balogh, László Kametler, Ferenc Kovács |
|---|---|
| Přispěvatelé: | Faculty of Animal Science, Research Group of Animal Breeding and Animal Hygiene, University of Kaposvár, Department of Nutrition, Szent Istvan University, Lehrstuhl für Tierhygiene, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Fusarium
Swine Health Toxicology and Mutagenesis Metabolite Statistics as Topic Food Contamination Ileum Kidney Toxicology Fumonisins 01 natural sciences Lipid peroxidation Feces chemistry.chemical_compound 0404 agricultural biotechnology Fumonisin Blood plasma medicine Animals Food science Biotransformation Fumonisin B1 Chromatography biology 010401 analytical chemistry Public Health Environmental and Occupational Health food and beverages Life Sciences 04 agricultural and veterinary sciences General Chemistry General Medicine Mycotoxins biology.organism_classification Animal Feed 040401 food science Carcinogens Environmental 0104 chemical sciences Red blood cell medicine.anatomical_structure Adipose Tissue Liver chemistry Food Science |
| Zdroj: | Food Additives and Contaminants Food Additives and Contaminants, 2007, 25 (01), pp.88-96. ⟨10.1080/02652030701546180⟩ |
| DOI: | 10.1080/02652030701546180⟩ |
| Popis: | The absorption, distribution and elimination of fumonisin B(1) (and B(2)) after oral administration of Fusarium verticillioides (MRC 826) fungal culture, mixed into the experimental feed for 10 days, was studied in weaned barrows. In order to determine the absorption of FB(1) from the feed marked by chromium oxide, a special T-cannula was implanted into the distal part of pigs' ileum. During the feeding of toxin-containing diet (45 mg FB(1) kg(-1)) and until the tenth day after the end of treatment, the total quantity of urine and faeces was collected and their toxin content analysed. At the end of the trial, samples of lung, liver, kidney, brain, muscle, and fat were also collected and their fumonisin content analysed by LC-MS. The fumonisins appeared to decrease the reduced glutathione content in blood plasma and red blood cell haemolysate, possibly associated with in vivo lipid peroxidation. From a data set of 80 individual data and the concentration and rate of C(r) and fumonisins (FB(1), partially hydrolysed FB(1) and aminopentol) in the chymus, it could be established that the accumulative absorption of fumonisin B(1) was 3.9% +/- 0.7%. In the chymus, the FB(1) conversions into aminopentol and partially hydrolysed FB(1) were 1.0 and 3.9%, respectively. The degree of metabolism in faeces was variable, although the main product was the partially hydrolysed form, with very small amounts of the aminopentol moiety being recovered. In the investigated tissues the FB(1) conversion to aminopentol and partially hydrolysed FB(1) was 30 and 20%, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|