v-src Inhibits Differentiation via an Extracellular Intermediate(s)

Autor:	P R, Langer-Safer, S R, Lehrman, A M, Skalka
Rok vydání:	1985
Předmět:	Cell Cycle Retroviridae Proteins Cell Differentiation Cell Biology Cell Transformation Viral Cell Line Culture Media Oncogene Protein pp60(v-src) Mice Adipose Tissue Animals Growth Substances Molecular Biology Research Article
Zdroj:	Molecular and Cellular Biology. 5:2847-2850
ISSN:	1098-5549
DOI:	10.1128/mcb.5.10.2847-2850.1985
Popis:	Murine 3T3L1 preadipocytes transformed by avian sarcoma virus were unable to differentiate in response to insulin or dexamethasone plus 1-methyl-3-isobutylxanthine, both potent inducers of differentiation of the nontransformed 3T3L1 parental line. Conditioned medium from transformed cells contained a relatively heat-stable factor(s) which inhibited the differentiation of untransformed parental 3T3L1 cells but did not induce any changes in their morphology. A protease-sensitive mitogen was also detected in the medium. The relationship between the two activities remains to be elucidated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4953b347189f4652299161a052bf23e8 https://doi.org/10.1128/mcb.5.10.2847-2850.1985 Zobrazit plný text záznamu