Higher spatial resolution improves the interpretation of the extent of ventricular trabeculation
| Autor: | Mary N. Sheppard, Allard C. van der Wal, Steffen E. Petersen, Vincent M. Christoffels, Bram F. Coolen, Hanne C. E. Riekerk, Gustav J. Strijkers, Roelof-Jan Oostra, Bjarke Jensen |
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| Přispěvatelé: | Biomedical Engineering and Physics, ACS - Atherosclerosis & ischemic syndromes, AMS - Amsterdam Movement Sciences, Pathology, ACS - Heart failure & arrhythmias, Medical Biology, ACS - Amsterdam Cardiovascular Sciences, ARD - Amsterdam Reproduction and Development |
| Rok vydání: | 2021 |
| Předmět: |
Histology
Heart Ventricles Population Cardiomyopathy Autopsy Context (language use) heart medicine Humans magnetic resonance imaging noncompaction education Molecular Biology Ecology Evolution Behavior and Systematics Original Paper education.field_of_study Isolated Noncompaction of the Ventricular Myocardium medicine.diagnostic_test business.industry Human heart Magnetic resonance imaging Cell Biology Anatomy medicine.disease Left ventricular noncompaction cardiomyopathy Original Papers medicine.anatomical_structure Ventricle Cardiomyopathies business cardiomyopathy Developmental Biology |
| Zdroj: | Journal of Anatomy Journal of anatomy, 240(2), 357-375. Wiley-Blackwell |
| ISSN: | 1469-7580 0021-8782 |
| Popis: | The ventricular walls of the human heart comprise an outer compact layer and an inner trabecular layer. In the context of an increased pre‐test probability, diagnosis left ventricular noncompaction cardiomyopathy is given when the left ventricle is excessively trabeculated in volume (trabecular vol >25% of total LV wall volume) or thickness (trabecular/compact (T/C) >2.3). Here, we investigated whether higher spatial resolution affects the detection of trabeculation and thus the assessment of normal and excessively trabeculated wall morphology. First, we screened left ventricles in 1112 post‐natal autopsy hearts. We identified five excessively trabeculated hearts and this low prevalence of excessive trabeculation is in agreement with pathology reports but contrasts the prevalence of approximately 10% of the population found by in vivo non‐invasive imaging. Using macroscopy, histology and low‐ and high‐resolution MRI, the five excessively trabeculated hearts were compared with six normal hearts and seven abnormally trabeculated and excessive trabeculation‐negative hearts. Some abnormally trabeculated hearts could be considered excessively trabeculated macroscopically because of a trabecular outflow or an excessive number of trabeculations, but they were excessive trabeculation‐negative when assessed with MRI‐based measurements (T/C Jensen et al. show that higher spatial resolution may affect the sensitivity of diagnostic measurements of noncompaction and in addition could allow for novel measurements such as counting of trabeculations. |
| Databáze: | OpenAIRE |
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