Topical hydrogel matrix loaded with Simvastatin microparticles for enhanced wound healing activity
| Autor: | BN VedhaHari, S Yasasvini, D. Ramyadevi, Anusa Rs, PC Prabhu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Simvastatin
Materials science Bioengineering Nanotechnology macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences Hydrogel Polyethylene Glycol Dimethacrylate Biomaterials Chitosan chemistry.chemical_compound X-Ray Diffraction In vivo Spectroscopy Fourier Transform Infrared medicine Animals Rats Wistar Skin Drug Carriers Wound Healing technology industry and agriculture Poloxamer 021001 nanoscience & nanotechnology Rats 0104 chemical sciences Drug Liberation chemistry Mechanics of Materials Polyvinyl Alcohol Drug delivery Self-healing hydrogels Microscopy Electron Scanning Hydroxymethylglutaryl-CoA Reductase Inhibitors Swelling medicine.symptom 0210 nano-technology Wound healing Biomedical engineering medicine.drug |
| Zdroj: | Materials Science and Engineering: C. 72:160-167 |
| ISSN: | 0928-4931 |
| Popis: | A prolonged release drug delivery system was developed by loading Simvastatin-chitosan microparticles into poly vinyl alcohol (PVA) hydrogels for enhanced wound healing efficiency. The microparticles prepared by ionic gelation method with varying composition of chitosan and surfactants (Tween 80/Pluronic F-127) were optimized for entrapment efficiency, morphology and drug-polymer interactions. Microparticles prepared with 0.3% between 80 and 0.5:5 chitosan: drug ratio showed maximum entrapment efficiency of 82% with spherical morphology and mild interaction between drug and chitosan. 5% PVA solutions loaded with pure drug and drug loaded microparticles at three different doses (2.5mg, 5mg and 10mg equivalent of drug) were chemically cross linked using gluteraldehyde and HCl. The formulated hydrogels were optimized for swelling, in vitro release behavior and in vivo wound healing effect. Hydrogels containing 2.5mg equivalent dose of Simvastatin microparticles exhibited maximum cumulative percentage drug release of 92% (n=3) at the end of 7days. The in vitro drug release data was supported by the higher swelling index of the low dose hydrogels. The in vivo wound healing study was performed using Wistar rats (n=30, 5 groups with 6 animals in each group) for the formulated hydrogels (at 3 doses) and compared with the untreated animals and the positive control group treated with conventional topical Simvastatin ointment (1%). The wound healing effect was comparable to the in vitro results, wherein the animals treated with low dose hydrogels (replaced every 7days) exhibited considerable reduction in the wound area compared to medium and high dose hydrogels. Statistically significant difference (P |
| Databáze: | OpenAIRE |
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